MIOS - meiosis regulator for oocyte development Gene

Also Known as MIO; Sea4; Yulink

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54468

About MIOS

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:7,566,884-7,609,144 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in prostate (RPKM 7.9), testis (RPKM 7.5) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

MIOS Products (5)

mRNA Protein Name
NM_001370076.1 NP_001357005.1 GATOR complex protein MIOS isoform 1
NM_001370077.1 NP_001357006.1 GATOR complex protein MIOS isoform 1
NM_001370078.1 NP_001357007.1 GATOR complex protein MIOS isoform 2
NM_001370080.1 NP_001357009.1 GATOR complex protein MIOS isoform 1
NM_019005.4 NP_061878.3 GATOR complex protein MIOS isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25263562 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
23723238 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35831510 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35831510 GOA
involved in protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
23723238 GOA
Cellular Component GO Annotation Evidence References Source
part of GATOR2 complex IDA
IDA: Inferred from direct assay
35831510 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
28199306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GATOR complex protein MIOS

  • H_DJ1159O04.1

MIOS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIOS Q9NXC5 SESN2 Homo sapiens P58004
Anti Tag CoIP
25263562
Intra
MIOS Q9NXC5 WDR24 Homo sapiens Q96S15
Anti Tag CoIP
25263562
Intra
MIOS Q9NXC5 WDR24 Homo sapiens Q96S15
GMS
28199315
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichothiodystrophy 6, Nonphotosensitive

  • TTD6

  • Nonphotosensitive Trichothiodystrophy 6

  • Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy

  • Trichothiodystrophy Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome
Sarcocystosis

  • Sarcosporidiosis

  • Sarcosporidiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08458 MIOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MIOS VGNC VGNC:63514
Macaca mulatta MIOS VGNC VGNC:74804
Canis familiaris MIOS VGNC VGNC:43239
Bos taurus MIOS VGNC VGNC:31481
Rattus norvegicus MIOS RGD RGD:1308432
Mus musculus MIOS MGD MGI:2182066
Others MIOS NCBI