UBC - ubiquitin C Gene

Also Known as HMG20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7316

About UBC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,911,646-124,914,650 (from NCBI)

This gene has 13 transcripts (splice variants), 60 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 1559.8), gall bladder (RPKM 1270.7) and 25 other tissues.

Summary

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or Polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of Other cell signaling pathways. [provided by RefSeq, Aug 2010]

UBC Products (1)

mRNA Protein Name
NM_021009.7 NP_066289.3 polyubiquitin-C

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8702753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBC Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (6 - 74)

ubiquitin

ubiquitin: Ubiquitin family (82 - 150)

ubiquitin

ubiquitin: Ubiquitin family (158 - 226)

ubiquitin

ubiquitin: Ubiquitin family (234 - 302)

ubiquitin

ubiquitin: Ubiquitin family (310 - 378)

ubiquitin

ubiquitin: Ubiquitin family (386 - 454)

ubiquitin

ubiquitin: Ubiquitin family (462 - 530)

ubiquitin

ubiquitin: Ubiquitin family (538 - 606)

ubiquitin

ubiquitin: Ubiquitin family (614 - 682)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
Protein Preferred Names Protein Names

polyubiquitin-C

UBC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBC P0CG48 BUB1B Homo sapiens O60566
Anti Tag CoIP
19407811
Intra
UBC P0CG48 MALT1 Homo sapiens Q9UDY8
Anti Tag CoIP
17948050
Intra
UBC P0CG48 UBE2G2 Homo sapiens P60604
Validated Y2H
32296183
Intra
UBC P0CG48 UBE2G2 Homo sapiens P60604
Y2H Array
32296183
Intra
UBC P0CG48 UBE2G2 Homo sapiens P60604
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 UBE3A Homo sapiens Q05086-3
Y2H Array
32296183
Intra
UBC P0CG48 UBE3A Homo sapiens Q05086-3
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 UBE3A Homo sapiens Q05086-3
Validated Y2H
32296183
Intra
UBC P0CG48 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
Intra
UBC P0CG48 MTURN Homo sapiens Q8N3F0
Validated Y2H
32296183
Intra
UBC P0CG48 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra
UBC P0CG48 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 LCK Homo sapiens P06239
NMR
18539162
Intra
UBC P0CG48 PRKCA Homo sapiens P17252
Anti Tag CoIP
18566587
Cross
UBC P0CG48 RAD23 Saccharomyces cerevisiae P32628
Pull Down
20059542
Intra
UBC P0CG48 ABCG2 Homo sapiens Q9UNQ0
Anti Bait CoIP
19909340
Intra
UBC P0CG48 NPLOC4 Homo sapiens Q8TAT6
Anti Tag CoIP
35271311
Intra
UBC P0CG48 NPLOC4 Homo sapiens Q8TAT6
ITC
17070805
Intra
UBC P0CG48 BMI1 Homo sapiens P35226
Pull Down
20601937
Intra
UBC P0CG48 YOD1 Homo sapiens Q5VVQ6
Validated Y2H
32296183
Cross
UBC P0CG48 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Cleavage
32726803
Cross
UBC P0CG48 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Probe Interaction
32726803
Cross
UBC P0CG48 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Probe Interaction
32726803
Cross
UBC P0CG48 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Cleavage
32726803
Intra
UBC P0CG48 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
Intra
UBC P0CG48 POLH Homo sapiens Q9Y253
Y2H
16763556
Intra
UBC P0CG48 POLH Homo sapiens Q9Y253
Pull Down
16763556
Intra
UBC P0CG48 CDIP1 Homo sapiens Q9H305
Validated Y2H
32296183
Intra
UBC P0CG48 SENP3 Homo sapiens Q9H4L4
Pull Down
19680224
Intra
UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
12857745
Intra
UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
8702753
Intra
UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
19427866
Intra
UBC P0CG48 NFKBIA Homo sapiens P25963
Anti Bait CoIP
17318178
Intra
UBC P0CG48 NFKBIA Homo sapiens P25963
Anti Tag CoIP
17318178
Intra
UBC P0CG48 NFKBIA Homo sapiens P25963
Pull Down
18539148
Intra
UBC P0CG48 ASAP2 Homo sapiens O43150
Pull Down
17255943
Intra
UBC P0CG48 SH3KBP1 Homo sapiens Q96B97
NMR
19111555
Intra
UBC P0CG48 SH3KBP1 Homo sapiens Q96B97
NMR
18680311
Intra
UBC P0CG48 ASAP1 Homo sapiens Q9ULH1
Pull Down
17255943
Intra
UBC P0CG48 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
17255943
Intra
UBC P0CG48 PARP1 Homo sapiens P09874
Anti Bait CoIP
19779455
Intra
UBC P0CG48 PARP1 Homo sapiens P09874
Pull Down
19779455
Intra
UBC P0CG48 MAP3K7 Homo sapiens O43318
Anti Tag CoIP
19820695
Intra
UBC P0CG48 MAP3K7 Homo sapiens O43318
Pull Down
16845370
Intra
UBC P0CG48 MAP3K7 Homo sapiens O43318
Anti Bait CoIP
19820695
Intra
UBC P0CG48 TRAF6 Homo sapiens Q9Y4K3
Anti Bait CoIP
17703191
Intra
UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
20059542
Intra
UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
9488668
Intra
UBC P0CG48 PSMD4 Homo sapiens P55036
Far-WB
8570649
Intra
UBC P0CG48 PSMD4 Homo sapiens P55036
SPR
19798103
Intra
UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
19796170
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17170702
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17159902
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
18566590
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
18309296
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
17139261
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17568776
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
18388957
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
19619542
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
18566590
Intra
UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
17268548
Intra
UBC P0CG48 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
UBC P0CG48 ELAVL1 Homo sapiens Q15717
Anti Tag CoIP
19322201
Intra
UBC P0CG48 MDM2 Homo sapiens Q00987
Anti Bait CoIP
18566590
Intra
UBC P0CG48 MDM2 Homo sapiens Q00987
Pull Down
19166840
Intra
UBC P0CG48 MDM2 Homo sapiens Q00987
Pull Down
18566590
Intra
UBC P0CG48 MDM2 Homo sapiens Q00987
Anti Tag CoIP
19098711
Intra
UBC P0CG48 GRK2 Homo sapiens P25098
Anti Bait CoIP
17006543
Intra
UBC P0CG48 NFATC4 Homo sapiens Q14934
Anti Bait CoIP
19026640
Intra
UBC P0CG48 NFATC4 Homo sapiens Q14934
Anti Tag CoIP
19026640
Intra
UBC P0CG48 RDH12 Homo sapiens Q96NR8
Anti Tag CoIP
20006610
Intra
UBC P0CG48 MYC Homo sapiens P01106
Anti Tag CoIP
19131971
Intra
UBC P0CG48 MAP3K4 Homo sapiens Q9Y6R4
Anti Tag CoIP
16256071
Intra
UBC P0CG48 MAP3K4 Homo sapiens Q9Y6R4
Anti Bait CoIP
16256071
Intra
UBC P0CG48 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
UBC P0CG48 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
UBC P0CG48 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
UBC P0CG48 XIAP Homo sapiens P98170
Pull Down
17318174
Intra
UBC P0CG48 XIAP Homo sapiens P98170
Anti Bait CoIP
17318174
Intra
UBC P0CG48 XIAP Homo sapiens P98170
Anti Tag CoIP
17318174
Intra
UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra
UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Pull Down
18239685
Intra
UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
UBC P0CG48 BCL2L12 Homo sapiens Q9HB09-1
Anti Tag CoIP
19376117
Intra
UBC P0CG48 BCL2L12 Homo sapiens Q9HB09-1
Pull Down
19376117
Intra
UBC P0CG48 NCK2 Homo sapiens O43639
NMR
18539162
Intra
UBC P0CG48 DENR Homo sapiens O43583
Anti Tag CoIP
16936636
Intra
UBC P0CG48 DENR Homo sapiens O43583
Anti Tag CoIP
16874301
Intra
UBC P0CG48 DENR Homo sapiens O43583
Anti Bait CoIP
16936636
Intra
UBC P0CG48 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
UBC P0CG48 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
UBC P0CG48 CSF3R Homo sapiens Q99062
Anti Tag CoIP
17363902
Intra
UBC P0CG48 CSF3R Homo sapiens Q99062
Pull Down
17363902
Intra
UBC P0CG48 RELA Homo sapiens Q04206
Pull Down
17183367
Intra
UBC P0CG48 RELA Homo sapiens Q04206
Anti Bait CoIP
17183367
Intra
UBC P0CG48 RELA Homo sapiens Q04206
Anti Bait CoIP
19322197
Intra
UBC P0CG48 RELA Homo sapiens Q04206
Pull Down
19322197
Intra
UBC P0CG48 POLI Homo sapiens Q9UNA4
Y2H
16763556
Intra
UBC P0CG48 NBR1 Homo sapiens Q14596
Pull Down
24879152
Intra
UBC P0CG48 NBR1 Homo sapiens Q14596
Pull Down
19427866
Intra
UBC P0CG48 NBR1 Homo sapiens Q14596
IF
19427866
Intra
UBC P0CG48 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Intra
UBC P0CG48 RYBP Homo sapiens Q8N488
ITC
17070805
Intra
UBC P0CG48 STAM Homo sapiens Q92783
NMR
12750381
Intra
UBC P0CG48 STAM Homo sapiens Q92783
SPR
12750381
Intra
UBC P0CG48 STAM Homo sapiens Q92783
NMR
19111546
Intra
UBC P0CG48 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra
UBC P0CG48 DAXX Homo sapiens Q9UER7
Y2H Pooling
20936779
Intra
UBC P0CG48 SNX9 Homo sapiens Q9Y5X1
Anti Tag CoIP
20491914
Intra
UBC P0CG48 ZFAND5 Homo sapiens O76080
Anti Tag CoIP
16424905
Intra
UBC P0CG48 ATXN3 Homo sapiens P54252-1
Anti Tag CoIP
19153604
Intra
UBC P0CG48 ATXN3 Homo sapiens P54252-1
Anti Bait CoIP
19153604
Intra
UBC P0CG48 ATXN3 Homo sapiens P54252-1
Pull Down
14559776
Intra
UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
UBC P0CG48 ADRM1 Homo sapiens Q16186
Pull Down
20059542
Intra
UBC P0CG48 RAD23B Homo sapiens P54727
Pull Down
20059542
Intra
UBC P0CG48 RAD23B Homo sapiens P54727
Validated Y2H
32296183
Cross
UBC P0CG48 Ikbkg Mus musculus O88522
Pull Down
19763089
Cross
UBC P0CG48 rev Human immunodeficiency virus P04325
Pull Down
17067581
Cross
UBC P0CG48 Rbck1 Rattus norvegicus Q62921
Anti Tag CoIP
19796170
Cross
UBC P0CG48 Rbck1 Rattus norvegicus Q62921
Pull Down
19796170
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Phlyctenulosis

  • Phlyctenular Keratoconjunctivitis

  • Strumous Ophthalmia
Middle East Respiratory Syndrome

  • Mers

  • Mers - [Middle East Respiratory Syndrome]
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Paget'S Disease Of Bone

  • Osteitis Deformans

  • Paget Disease Of Bone

  • Osseous Paget'S Disease

  • Paget Disease Of Bone, Familial

  • Bone Paget Disease

  • Familial Paget'S Disease Of Bone

  • Paget'S Bone Disease

  • Familial Paget Disease Of Bone

  • Paget Disease, Bone

  • Pdb

  • Pagets Bone Disease
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Ectodermal Dysplasia

  • Congenital Ectodermal Defect

  • Congenital Ectodermal Dysplasia

  • Ectodermal Dysplasia Syndrome

  • Dysplasia, Ectodermal
Angelman Syndrome

  • AS

  • Happy Puppet Syndrome

  • Happy Puppet Syndrome, Formerly

  • Puppetlike Syndrome
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120934 C25-140 Inhibitor 99.92% Unkown
HY-13811 NSC697923 99.90% Unkown
HY-115453 UBCS039 Activator 98.88% Unkown
HY-124602 DI-591 Inhibitor 98.36% Unkown
HY-W264347 DCN1-UBC12-IN-4 Inhibitor 95.10% Unkown
HY-126075A WS-383 Inhibitor 99.43% Unkown
HY-145169 AZ194 Inhibitor 99.45% Unkown
HY-157728 ML307 Inhibitor 99.10% Unkown
HY-161470 WS-384 98.23% Unkown
HY-RS18903 Ubb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20593 Rps27a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126075 WS-383 free base Inhibitor / Unkown
HY-125660 Leucettamol A / Unkown
HY-131667 Hdm2 E3 ligase inhibitor 1 / Unkown
HY-142691 DCN1-UBC12-IN-1 Inhibitor / Unkown
HY-142692 DCN1-UBC12-IN-3 Inhibitor / Unkown
HY-142694 DCN1-UBC12-IN-2 Inhibitor / Unkown
HY-145269 AL-GDa62 Inhibitor / Unkown
HY-156240 DI-1548 / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-RS12239 RPS27A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15334 UBC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111505A NAcM-OPT hydrochloride Inducer / Unkown
HY-RS17875 Ubc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20505 Uba52 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24344 Ubc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBC MGD MGI:98889
Rattus norvegicus UBC RGD RGD:621244
Bos taurus UBC VGNC VGNC:107263
Others UBC NCBI