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Cat. No.: HY-142692

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DCN1-UBC12-IN-3

DCN1-UBC12-IN-3 is potent and selective DCN1-UBC12 inhibitor with an IC₅₀ of 2.25 nM. Anticardiac fibrotic effect.

For research use only. We do not sell to patients.

CAS No.: 2374827-45-7
Formula: C₃₀H₃₀N₈O₃S₂
Molecular Weight:614.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DCN1-UBC12-IN-3 Chemical Structure

CAS No.: 2374827-45-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DCN1-UBC12-IN-3 is potent and selective DCN1-UBC12 inhibitor with an IC₅₀ of 2.25 nM. Anticardiac fibrotic effect^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast of cardiac tissue	IC₅₀	25.78 μM Compound: 49	Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay	[PMID: 34939411]

In Vitro

DCN1-UBC12-IN-3 (compound 49) possesses low cytotoxicity toward cardiac fibroblasts (CFs) with an IC₅₀ of 25 78 μM for 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2374827-45-7
Molecular Weight 614.74
Formula C₃₀H₃₀N₈O₃S₂
SMILES

N#CC1=C(C2=CC(OC)=C(OC)C(OC)=C2)N=C(SCC3=CC=C4C=CC=CC4=C3)N=C1SC5=NN=NN5CCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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