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WS-383 

Cat. No.: HY-126075A
Handling Instructions

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2.

For research use only. We do not sell to patients.

WS-383 Chemical Structure

WS-383 Chemical Structure

CAS No. : 2247544-02-9

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  • Biological Activity

  • Technical Information

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  • References

Description

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].

IC50 & Target

IC50: 11 nM (DCN1-UBC12 interaction)[1]

References
Molecular Weight

498.46

Formula

C₁₈H₂₁Cl₂N₉S₂

CAS No.

2247544-02-9

SMILES

CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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WS-383
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HY-126075A
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WS-383

Cat. No.: HY-126075A