2247544-02-9
2247544-02-9
Chemical Structure
WS-383
- CAS No.: 2247544-02-9
- Formula:C18H21Cl2N9S2
- Molecular Weight:498.46
IUPAC Name: 2-(5-((2-((4-chlorobenzyl)thio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio)-1H-tetrazol-1-yl)-N,N-dimethylethan-1-amine hydrochloride
InChIKey: LJZUAAKUJAXXHQ-UHFFFAOYSA-N
SMILES: CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23.Cl
Biological Activity: WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
WS-383 | 99.43% | WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
