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Cat. No.: HY-142694

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DCN1-UBC12-IN-2

DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC₅₀=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation.

For research use only. We do not sell to patients.

CAS No.: 2374827-47-9
Formula: C₂₃H₂₀ClN₇O₃S₂
Molecular Weight:542.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DCN1-UBC12-IN-2 Chemical Structure

CAS No.: 2374827-47-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast of cardiac tissue	IC₅₀	27.34 nM Compound: 39; DN-2	Cytotoxicity against Sprague-Dawley rat cardiac fibroblast incubated for 24 hrs by MTT assay Cytotoxicity against Sprague-Dawley rat cardiac fibroblast incubated for 24 hrs by MTT assay	[PMID: 34939411]
Fibroblast of cardiac tissue	IC₅₀	27.34 μM Compound: 39; DN-2	Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay	[PMID: 34939411]

In Vitro

DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC₅₀ of 27.34 μM for 24 h.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2374827-47-9
Molecular Weight 542.03
Formula C₂₃H₂₀ClN₇O₃S₂
SMILES

N#CC1=C(C2=CC(OC)=C(OC)C(OC)=C2)N=C(SCC3=CC=C(Cl)C=C3)N=C1SC4=NN=NN4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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