2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. WS-691

WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel (HY-B0015) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1. WS-691 increases the sensitivity of colon cancer cells to Paclitaxel.

For research use only. We do not sell to patients.

WS-691

WS-691 Chemical Structure

CAS No. : 2035417-32-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

WS-691 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel (HY-B0015) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1. WS-691 increases the sensitivity of colon cancer cells to Paclitaxel[1][2].

In Vitro

WS-691 (20 μM) reduces the IC50 of paclitaxel from 4.23 μM to 0.022 μM in paclitaxel-resistant cancer cells with ABCB1 overexpression, and exhibits no cytotoxicity when used alone[1].
WS-691 (0-40 μM; 20 min) stimulates the ATPase activity of ABCB1 to 2.5-fold of the basal activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WS-691 Related Antibodies
In Vivo

WS-691 (20 mg/kg; i.g.; daily; 21 days) significantly enhances the antitumor efficacy of paclitaxel in a SW620/Ad300 colorectal cancer xenograft model without causing observable liver toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (male, 5-6 weeks old, 15-17 g, subcutaneous inoculation of SW620/Ad300 cells)[2]
Dosage: 20 mg/kg (single agent); 20 mg/kg (in combination with paclitaxel 5 mg/kg)
Administration: i.g.; daily; 21 days;
Result: Showed little effect on tumor growth compared to vehicle group when used as a single agent.
Significantly reduced tumor volume and tumor weight compared to paclitaxel alone, paclitaxel plus verapamil, or vehicle group when combined with paclitaxel.
Induced more tumor cell death (evident as nuclear pyknosis in HE staining) and higher levels of tumor cell apoptosis (evident as bright green staining in TUNEL assays) compared to single-agent and control groups when combined with paclitaxel.
Caused no obvious liver injury when used alone or in combination with paclitaxel.
Molecular Weight

405.45

Formula

C20H16FN7S
CAS No.
SMILES

FC1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=C(N4)C=CC=C5)=NN32)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

WS-691 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WS-6912035417-32-2WS691WS 691P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYP3A4colorectal cancer xenograft modelhuman liver microsomesSW620/Ad300 cell lysatesABCC1ABCB1-overexpressed cancer cellsmultidrug-resistant cancerpaclitaxelpaclitaxel-resistant cancer cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
WS-691
Cat. No.:
HY-182253
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.