2035417-32-2
Chemical Structure
WS-691
- CAS No.: 2035417-32-2
- Formula:C20H16FN7S
- Molecular Weight:405.45
InChIKey: ZGRDQSSNSDLZLJ-UHFFFAOYSA-N
SMILES: FC1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=C(N4)C=CC=C5)=NN32)C=C1
Biological Activity: WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel (HY-B0015) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1. WS-691 increases the sensitivity of colon cancer cells to Paclitaxel[1][2].
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WS-691 | WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel (HY-B0015) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1. WS-691 increases the sensitivity of colon cancer cells to Paclitaxel. | |||||||||||||||||||||
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- [1]. Abdelhafiz AHA, et al. Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells. J Enzyme Inhib Med Chem. 2022;37(1):2710-2724. [Content Brief]
- [2]. Wang S, et al. Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators. J Med Chem. 2020 Dec 24;63(24):15979-15996. [Content Brief]
Keywords
