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Cat. No.: HY-142691

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DCN1-UBC12-IN-1

DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC₅₀ of 2.86 nM. Anticardiac fibrotic effect.

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CAS No.: 2374827-31-1
화학식: C₂₄H₂₃N₇O₃S₂
분자량:521.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DCN1-UBC12-IN-1 Chemical Structure

CAS No.: 2374827-31-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC₅₀ of 2.86 nM. Anticardiac fibrotic effect^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast of cardiac tissue	IC₅₀	9.97 μM Compound: 44	Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay	[PMID: 34939411]

In Vitro

DCN1-UBC12-IN-1 (compound 44) possesses low cytotoxicity toward cardiac fibroblasts (CFs) with an IC₅₀ of 9.97 μM for 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2374827-31-1
분자량 521.61
화학식 C₂₄H₂₃N₇O₃S₂
SMILES

N#CC1=C(C2=CC(OC)=C(OC)C(OC)=C2)N=C(SCC3=CC=C(C)C=C3)N=C1SC4=NN=NN4C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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