2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-58

Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells.

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Antitumor agent-58

Antitumor agent-58 Chemical Structure

CAS No. : 3036933-32-8

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Antitumor agent-58 Related Antibodies

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Description

Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells[1].

Cellular Effect
Cell Line Type Value Description References
BGC-823 IC50
23.31 μM
Compound: C18
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32682202]
GES1 IC50
17.32 μM
Compound: C18
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32682202]
HGC-27 IC50
9.54 μM
Compound: C18
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32682202]
MGC-803 IC50
2.68 μM
Compound: C18
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 32682202]
Molecular Weight

567.63

Formula

C27H28F3N9S
CAS No.
SMILES

CC1=NC2=NC(SCC3=CC=C(C=C3)C(F)(F)F)=NN2C(N4CC[C@H]([C@H](C4)N(C5=NC=NC6=C5C=CN6)C)C)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-58 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-583036933-32-8Antitumor agent58Antitumor agent 58Apoptosiscolony formationcell migrationapoptosisp38JNKtumor growthInhibitorinhibitorinhibit

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