Antitumor agent-58
Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells.
For research use only. We do not sell to patients.
- CAS No.: 3036933-32-8
- Formula: C27H28F3N9S
- Molecular Weight:567.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
23.31 μM
Compound: C18
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Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32682202] |
| GES1 | IC50 |
17.32 μM
Compound: C18
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Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32682202] |
| HGC-27 | IC50 |
9.54 μM
Compound: C18
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Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32682202] |
| MGC-803 | IC50 |
2.68 μM
Compound: C18
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Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32682202] |
Chemical Information
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CAS No. 3036933-32-8
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Molecular Weight 567.63
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Formula C27H28F3N9S
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SMILES
CC1=NC2=NC(SCC3=CC=C(C=C3)C(F)(F)F)=NN2C(N4CC[C@H]([C@H](C4)N(C5=NC=NC6=C5C=CN6)C)C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-58 Related Classifications
HY-146323 Related Classifications
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