1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
  2. Sirtuin
    Autophagy
  3. UBCS039

UBCS039 

Cat. No.: HY-115453 Purity: 98.55%
Handling Instructions

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.

For research use only. We do not sell to patients.

UBCS039 Chemical Structure

UBCS039 Chemical Structure

CAS No. : 358721-70-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 280 In-stock
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50 mg USD 960 In-stock
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100 mg USD 1650 In-stock
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Description

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].

IC50 & Target[1]

SIRT6

38 μM (EC50)

In Vitro

UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2].
UBCS039 leads to autophagosome accumulation in human cancer cells[2].
UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2].

Western Blot Analysis[2]

Cell Line: Human H1299 cells.
Concentration: 75 μM.
Incubation Time: 48 and 72 hours.
Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

Western Blot Analysis[2]

Cell Line: Human H1299 cells.
Concentration: 75 μM.
Incubation Time: 48 and 72 hours.
Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

Cell Proliferation Assay[2]

Cell Line: Human H1299 cells.
Concentration: 100 μM.
Incubation Time: 48 and 72 hours.
Result: Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
Molecular Weight

247.29

Formula

C₁₆H₁₃N₃

CAS No.

358721-70-7

SMILES

N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (505.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0438 mL 20.2192 mL 40.4384 mL
5 mM 0.8088 mL 4.0438 mL 8.0877 mL
10 mM 0.4044 mL 2.0219 mL 4.0438 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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UBCS039
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HY-115453
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