PLSCR4 - phospholipid scramblase 4 Gene
Also Known as TRA1
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 57088
About PLSCR4
Cytogenetic location: 3q24
Genomic coordinates (GRCh38): 3:146,192,335-146,251,105 (from NCBI)
This gene has 11 transcripts (splice variants), 408 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 22.0), gall bladder (RPKM 21.1) and 24 other tissues.
Summary
Enables CD4 receptor binding activity and enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to act upstream of or within cellular response to lipopolysaccharide. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
PLSCR4 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001128304.2 | NP_001121776.1 | phospholipid scramblase 4 isoform a |
| NM_001128305.2 | NP_001121777.1 | phospholipid scramblase 4 isoform a |
| NM_001128306.2 | NP_001121778.1 | phospholipid scramblase 4 isoform b |
| NM_001177304.2 | NP_001170775.1 | phospholipid scramblase 4 isoform c |
| NM_020353.3 | NP_065086.2 | phospholipid scramblase 4 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables CD4 receptor binding |
IPI
IPI: Inferred from physical interaction
|
19333378 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
19333378 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
19333378 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
PLSCR4 Protein Structure
Scramblase
Scramblase: Scramblase (100 - 322)
- 0
- 100
- 200
- 300
- 329 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
phospholipid scramblase 4 |
|
PLSCR4 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TEKT5 | Homo sapiens | Q96M29 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TEKT5 | Homo sapiens | Q96M29 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP8-1 | Homo sapiens | Q8IUC2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP8-1 | Homo sapiens | Q8IUC2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NID2 | Homo sapiens | Q8IV28 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NID2 | Homo sapiens | Q8IV28 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRT82 | Homo sapiens | Q9NSB4 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRT82 | Homo sapiens | Q9NSB4 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRT82 | Homo sapiens | Q9NSB4 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-5 | Homo sapiens | Q3LI72 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-5 | Homo sapiens | Q3LI72 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CLPP | Homo sapiens | Q16740 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CLPP | Homo sapiens | Q16740 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE2B | Homo sapiens | O14633 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE2B | Homo sapiens | O14633 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP1-5 | Homo sapiens | Q9BYS1 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP1-5 | Homo sapiens | Q9BYS1 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | PCSK5 | Homo sapiens | Q92824-2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | PCSK5 | Homo sapiens | Q92824-2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE1A | Homo sapiens | Q5T7P2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE1A | Homo sapiens | Q5T7P2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | FCHO1 | Homo sapiens | A0A0C3SFZ9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | FCHO1 | Homo sapiens | A0A0C3SFZ9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-1 | Homo sapiens | Q3LI64 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-1 | Homo sapiens | Q3LI64 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CES1 | Homo sapiens | P23141-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CES1 | Homo sapiens | P23141-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-6 | Homo sapiens | Q3LI70 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-6 | Homo sapiens | Q3LI70 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | SLC15A2 | Homo sapiens | Q16348 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | SLC15A2 | Homo sapiens | Q16348 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RBP3 | Homo sapiens | P10745 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RBP3 | Homo sapiens | P10745 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TENM4 | Homo sapiens | Q6N022 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TENM4 | Homo sapiens | Q6N022 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP21-2 | Homo sapiens | Q3LI59 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP21-2 | Homo sapiens | Q3LI59 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBC | Homo sapiens | P0CG48 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBC | Homo sapiens | P0CG48 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBA52 | Homo sapiens | P62987 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBA52 | Homo sapiens | P62987 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RPS27A | Homo sapiens | P62979 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RPS27A | Homo sapiens | P62979 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TRIP13 | Homo sapiens | Q15645 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TRIP13 | Homo sapiens | Q15645 | 32296183 | |
|
Cross
|
PLSCR4 | Q9NRQ2 | Hoxa1 | Mus musculus | P09022 | 23088713 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBB | Homo sapiens | P0CG47 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | UBB | Homo sapiens | P0CG47 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TRIM42 | Homo sapiens | Q8IWZ5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TRIM42 | Homo sapiens | Q8IWZ5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CRCT1 | Homo sapiens | Q9UGL9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CRCT1 | Homo sapiens | Q9UGL9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CRCT1 | Homo sapiens | Q9UGL9 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RBPMS | Homo sapiens | Q93062-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RBPMS | Homo sapiens | Q93062-3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | MTUS2 | Homo sapiens | Q5JR59 | 21516116 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | HDHD3 | Homo sapiens | Q9BSH5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | HDHD3 | Homo sapiens | Q9BSH5 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | INTS11 | Homo sapiens | Q5TA45 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | INTS11 | Homo sapiens | Q5TA45 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TSPAN4 | Homo sapiens | O14817 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | TSPAN4 | Homo sapiens | O14817 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | GATA1 | Homo sapiens | P15976-2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | GATA1 | Homo sapiens | P15976-2 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 31515488 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 | |
|
Intra
|
PLSCR4 | Q9NRQ2 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Atypical Choroid Plexus Papilloma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS10743 | PLSCR4 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | PLSCR4 | VGNC | VGNC:33053 |
| Mus musculus | PLSCR4 | MGD | MGI:2143267 |
| Canis familiaris | PLSCR4 | VGNC | VGNC:44713 |
| Macaca mulatta | PLSCR4 | VGNC | VGNC:76036 |
| Rattus norvegicus | PLSCR4 | RGD | RGD:1311693 |
| Others | PLSCR4 | NCBI |
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