PLSCR4 - phospholipid scramblase 4 Gene

Homo sapiens

Also known as TRA1

Gene ID: 57088 | Gene type: protein coding

About PLSCR4

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:146,192,335-146,251,105 (from NCBI)

This gene has 11 transcripts (splice variants), 408 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 22.0), gall bladder (RPKM 21.1) and 24 other tissues.

Summary

Enables CD4 receptor binding activity and Enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to act upstream of or within cellular response to lipopolysaccharide. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLSCR4 Products(5)

mRNA	Protein	Name
NM_001128304.2	NP_001121776.1	phospholipid scramblase 4 isoform a
NM_001128305.2	NP_001121777.1	phospholipid scramblase 4 isoform a
NM_001128306.2	NP_001121778.1	phospholipid scramblase 4 isoform b
NM_001177304.2	NP_001170775.1	phospholipid scramblase 4 isoform c
NM_020353.3	NP_065086.2	phospholipid scramblase 4 isoform a

PLSCR4 Protein Structure

Scramblase

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

phospholipid scramblase 4

Ca(2+)-dependent phospholipid scramblase 4

Related Diseases

Diseases

Alias

Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10743	PLSCR4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLSCR4	VGNC	VGNC:33053
Mus musculus	PLSCR4	MGD	MGI:2143267
Canis familiaris	PLSCR4	VGNC	VGNC:44713
Macaca mulatta	PLSCR4	VGNC	VGNC:76036
Rattus norvegicus	PLSCR4	RGD	RGD:1311693

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