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TSPAN4 - tetraspanin 4 Gene

Also Known as NAG2; NAG-2; TM4SF7; TSPAN-4; TETRASPAN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7106

About TSPAN4

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:842,852-867,111 (from NCBI)

This gene has 20 transcripts (splice variants), 200 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 26.0), spleen (RPKM 24.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and Other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TSPAN4 Products (7)

mRNA	Protein	Name
NM_001025234.2	NP_001020405.1	tetraspanin-4 isoform a
NM_001025235.2	NP_001020406.1	tetraspanin-4 isoform a
NM_001025236.2	NP_001020407.1	tetraspanin-4 isoform a
NM_001025237.2	NP_001020408.1	tetraspanin-4 isoform a
NM_001025238.2	NP_001020409.1	tetraspanin-4 isoform a
NM_001025239.2	NP_001020410.1	tetraspanin-4 isoform b
NM_003271.5	NP_003262.1	tetraspanin-4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antigen binding	IDA IDA: Inferred from direct assay	9360996	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	9360996	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	9360996	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	9360996	GOA
located in vesicle	IDA IDA: Inferred from direct assay	9360996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tetraspanin-4	novel antigen 2

TSPAN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSPAN4	O14817	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	TSPAN4	O14817	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	TSPAN4	O14817	LCE3C	Homo sapiens	Q5T5A8	Validated Y2H	32296183
Intra	TSPAN4	O14817	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	32296183
Intra	TSPAN4	O14817	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	TSPAN4	O14817	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	TSPAN4	O14817	SGPL1	Homo sapiens	O95470	Validated Y2H	32296183
Intra	TSPAN4	O14817	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	TSPAN4	O14817	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	TSPAN4	O14817	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	TSPAN4	O14817	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	TSPAN4	O14817	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	TSPAN4	O14817	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	TSPAN4	O14817	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	TSPAN4	O14817	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	TSPAN4	O14817	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
Intra	TSPAN4	O14817	NR4A3	Homo sapiens	Q92570	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	NR4A3	Homo sapiens	Q92570	Y2H Array	32296183
Intra	TSPAN4	O14817	NR4A3	Homo sapiens	Q92570	Validated Y2H	32296183
Intra	TSPAN4	O14817	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	TSPAN4	O14817	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	TSPAN4	O14817	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	TSPAN4	O14817	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	TSPAN4	O14817	TMEM106A	Homo sapiens	Q96A25	Y2H Array	32296183
Intra	TSPAN4	O14817	TMEM106A	Homo sapiens	Q96A25	Validated Y2H	32296183
Intra	TSPAN4	O14817	TMEM106A	Homo sapiens	Q96A25	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	LCE3D	Homo sapiens	Q9BYE3	Validated Y2H	32296183
Intra	TSPAN4	O14817	EVA1A	Homo sapiens	Q9H8M9	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	EVA1A	Homo sapiens	Q9H8M9	Validated Y2H	32296183
Intra	TSPAN4	O14817	EVA1A	Homo sapiens	Q9H8M9	Y2H Array	32296183
Intra	TSPAN4	O14817	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	TSPAN4	O14817	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	TSPAN4	O14817	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	TSPAN4	O14817	FRS3	Homo sapiens	O43559	Validated Y2H	32296183
Intra	TSPAN4	O14817	OTX1	Homo sapiens	P32242	Validated Y2H	32296183
Intra	TSPAN4	O14817	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	TSPAN4	O14817	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	TSPAN4	O14817	GRN	Homo sapiens	P28799	Validated Y2H	32296183
Intra	TSPAN4	O14817	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	TSPAN4	O14817	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	TSPAN4	O14817	LCE3A	Homo sapiens	Q5TA76	Validated Y2H	32296183
Intra	TSPAN4	O14817	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	TSPAN4	O14817	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bladder Exstrophy	Exstrophy Of The Bladder Classic Exstrophy Of The Bladder
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Glioblastoma Proneural Subtype

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15170	TSPAN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TSPAN4	VGNC	VGNC:101421
Rattus norvegicus	TSPAN4	RGD	RGD:1305810
Felis catus	TSPAN4	VGNC	VGNC:66634
Canis familiaris	TSPAN4	VGNC	VGNC:56097
Bos taurus	TSPAN4	VGNC	VGNC:36439
Mus musculus	TSPAN4	MGD	MGI:1928097
Others	TSPAN4	NCBI