CHRD - chordin Gene

Homo sapiens

Gene ID: 8646 | Gene type: protein coding

About CHRD

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,380,054-184,390,739 (from NCBI)

This gene has 17 transcripts (splice variants), 102 orthologues and 19 paralogues. Broad expression in endometrium (RPKM 10.5), liver (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]

CHRD Products(4)

mRNA	Protein	Name
NM_001304472.2	NP_001291401.1	chordin isoform 2 precursor
NM_001304473.2	NP_001291402.1	chordin isoform 3
NM_001304474.2	NP_001291403.1	chordin isoform 3
NM_003741.4	NP_003732.2	chordin isoform 1 precursor

CHRD Protein Structure

VWC

CHRD

VWC

0
200
400
600
800
955 a.a.

Protein Preferred Names

Protein Names

chordin

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Tarsal-Carpal Coalition Syndrome

TCC	Tarsal Carpal Coalition Syndrome
Nog-Related-Symphalangism Spectrum Disorder

Holoprosencephaly 4

HPE4	Holoprosencephaly-4
Holoprosencephaly, Type 4

Brachydactyly, Type B2

Brachydactyly Type B2	BDB2
Brachydactyly B2

Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome	Wzs
Pierre Robin Syndrome With Fetal Chondrodysplasia	OSMEDA
Weissenbacher-Zweymüller Syndrome	Heterozygous Osmed
Stickler Syndrome, Type 3	Osmed, Heterozygous
Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly	Stickler Syndrome, Type Iii, Formerly
Stl3, Formerly	Piere-Robin Syndrome
Pierre Robin Malformation	Heterozygous Otospondylomegaepiphyseal Dysplasia
Autosomal Dominant Otospondylomegaepiphyseal Dysplasia	Ad Osmed
Stickler Syndrome Type 3	Stickler Syndrome, Non-Ocular Type
Stickler-Like Syndrome	Stickler Syndrome 3
Stickler Syndrome Non-Ocular Type	Stickler Syndrome Type Iii
Stl3	Weissenbacher-Zweymueller Syndrome
Stickler Syndrome, Type Iii	Pierre Robin Syndrome
Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant

Sclerosteosis 1

SOST1	Sost
Cortical Hyperostosis With Syndactyly	Sclerosteosis
Sclerosteosis, Type 1

Proximal Symphalangism

Cushing'S Symphalangism	Symphalangism, Proximal
Hereditary Absence Of Proximal Interphalangeal Joints	Strasburger-Hawkins-Eldridge Syndrome
Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome	Symphalangism, Proximal, 1a
Symphalangism, Proximal, 1b	Vessel'S Syndrome
Symphalangism, Cushing Type

Agnathia-Otocephaly Complex

Otocephaly	Holoprosencephaly-Agnathia
Dysgnathia Complex Agnathia-Holoprosencephaly	AGOTC
Agnathia-Holoprosencephaly-Situs Inversus Syndrome	Dysgnathia Complex
Agnathia-Holoprosencephaly	Cervical Auricle

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Orofacial Cleft

Cleft, Orofacial

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02656	CHRD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHRD	VGNC	VGNC:39228
Bos taurus	CHRD	VGNC	VGNC:27316
Macaca mulatta	CHRD	VGNC	VGNC:71042
Rattus norvegicus	CHRD	RGD	RGD:620181
Mus musculus	CHRD	MGD	MGI:1313268
Felis catus	CHRD	VGNC	VGNC:60870
Others	CHRD	NCBI