SPRY1 - sprouty RTK signaling antagonist 1 Gene
Also Known as hSPRY1
Species: Homo sapiens
About SPRY1
This gene has 9 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues.
Summary
Involved in negative regulation of Fibroblast Growth Factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
SPRY1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001258038.2 | NP_001244967.1 | protein sprouty homolog 1 |
| NM_001258039.1 | NP_001244968.1 | protein sprouty homolog 1 |
| NM_001375410.1 | NP_001362339.1 | protein sprouty homolog 1 |
| NM_005841.3 | NP_005832.1 | protein sprouty homolog 1 |
| NM_199327.3 | NP_955359.1 | protein sprouty homolog 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21988832 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of fibroblast growth factor receptor signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
16481357 | GOA |
SPRY1 Protein Structure
Sprouty: Sprouty protein (Spry) (186 - 298)
- 0
- 100
- 200
- 300
- 319 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein sprouty homolog 1 |
|
SPRY1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-5 | Homo sapiens | P60370 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-5 | Homo sapiens | P60370 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-7 | Homo sapiens | P60409 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-7 | Homo sapiens | P60409 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-7 | Homo sapiens | P60409 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CREB5 | Homo sapiens | Q02930-3 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | CREB5 | Homo sapiens | Q02930-3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CREB5 | Homo sapiens | Q02930-3 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP10-11 | Homo sapiens | P60412 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE3C | Homo sapiens | Q5T5A8 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1B | Homo sapiens | Q5T7P3 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | LCE1B | Homo sapiens | Q5T7P3 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | LCE4A | Homo sapiens | Q5TA78 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE4A | Homo sapiens | Q5TA78 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE4A | Homo sapiens | Q5TA78 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2A | Homo sapiens | Q5TA79 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2D | Homo sapiens | Q5TA82 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2D | Homo sapiens | Q5TA82 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | R3HDM2 | Homo sapiens | Q9Y2K5-2 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | KRTAP9-3 | Homo sapiens | Q9BYQ3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | PRKAB2 | Homo sapiens | O43741 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CCDC57 | Homo sapiens | Q2TAC2-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CDR2L | Homo sapiens | Q86X02 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MB21D2 | Homo sapiens | Q8IYB1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MB21D2 | Homo sapiens | Q8IYB1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MB21D2 | Homo sapiens | Q8IYB1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1D | Homo sapiens | Q5T752 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1D | Homo sapiens | Q5T752 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1D | Homo sapiens | Q5T752 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | TFAP2D | Homo sapiens | Q7Z6R9 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE5A | Homo sapiens | Q5TCM9 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | PCSK5 | Homo sapiens | Q92824-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | PCSK5 | Homo sapiens | Q92824-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | PCSK5 | Homo sapiens | Q92824-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | FBLN1 | Homo sapiens | P23142-4 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | VWC2 | Homo sapiens | Q2TAL6 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | VWC2 | Homo sapiens | Q2TAL6 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | VWC2 | Homo sapiens | Q2TAL6 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1F | Homo sapiens | Q5T754 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1F | Homo sapiens | Q5T754 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1F | Homo sapiens | Q5T754 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1A | Homo sapiens | Q5T7P2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1A | Homo sapiens | Q5T7P2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1A | Homo sapiens | Q5T7P2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2C | Homo sapiens | Q5TA81 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2C | Homo sapiens | Q5TA81 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE2C | Homo sapiens | Q5TA81 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | GNE | Homo sapiens | Q9Y223-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | GUCD1 | Homo sapiens | Q96NT3-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | NTM | Homo sapiens | Q9P121-3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | TGM7 | Homo sapiens | Q96PF1 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE1C | Homo sapiens | Q5T751 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | PRKAA2 | Homo sapiens | P54646 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ANKRD11 | Homo sapiens | X5D778 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF441 | Homo sapiens | Q8N8Z8 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | FARS2 | Homo sapiens | O95363 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | GEMIN4 | Homo sapiens | P57678 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | GEMIN4 | Homo sapiens | P57678 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | GEMIN4 | Homo sapiens | P57678 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF330 | Homo sapiens | Q9Y3S2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF330 | Homo sapiens | Q9Y3S2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF330 | Homo sapiens | Q9Y3S2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Cross
|
SPRY1 | O43609 | Hoxa1 | Mus musculus | P09022 | 23088713 | |
|
Intra
|
SPRY1 | O43609 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | ZNF23 | Homo sapiens | P17027 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE3D | Homo sapiens | Q9BYE3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | UBASH3A | Homo sapiens | P57075-2 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | OTX1 | Homo sapiens | P32242 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HOXA1 | Homo sapiens | P49639 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | HOXA1 | Homo sapiens | P49639 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | SPRY2 | Homo sapiens | O43597 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | SPRY2 | Homo sapiens | O43597 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | FHL5 | Homo sapiens | Q5TD97 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | FHL5 | Homo sapiens | Q5TD97 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | FHL5 | Homo sapiens | Q5TD97 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP3-2 | Homo sapiens | Q9BYR7 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP3-2 | Homo sapiens | Q9BYR7 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRTAP3-2 | Homo sapiens | Q9BYR7 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | LCE3A | Homo sapiens | Q5TA76 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 31515488 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SPRY1 | O43609 | CHRD | Homo sapiens | Q9H2X0 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
SPRY1 | O43609 | KRT31 | Homo sapiens | Q15323 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Adrenal Cortical Adenocarcinoma |
|
|
| Legius Syndrome |
|
|
| Colon Squamous Cell Carcinoma |
|
|
| Pulsating Exophthalmos |
|
|
| Noonan Syndrome With Multiple Lentigines |
|
|
| Cardiofaciocutaneous Syndrome 1 |
|
|
| Rasopathy |
|
|
| Renal Hypodysplasia/Aplasia 1 |
|
|
| Rhabdomyosarcoma |
|
|
| Crouzon Syndrome |
|
|
| Vesicoureteral Reflux |
|
|
| Cakut |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | SPRY1 | MGD | MGI:1345139 |
| Macaca mulatta | SPRY1 | VGNC | VGNC:77867 |
| Rattus norvegicus | SPRY1 | RGD | RGD:1309293 |
| Bos taurus | SPRY1 | VGNC | VGNC:35241 |
| Felis catus | SPRY1 | VGNC | VGNC:65649 |
| Others | SPRY1 | NCBI |