SPRY2 - sprouty RTK signaling antagonist 2 Gene

Also Known as IGAN3; hSPRY2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10253

About SPRY2

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:80,335,976-80,341,126 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to Fibroblast Growth Factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on Fibroblast Growth Factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

SPRY2 Products (4)

mRNA Protein Name
NM_001318536.1 NP_001305465.1 protein sprouty homolog 2
NM_001318537.1 NP_001305466.1 protein sprouty homolog 2
NM_001318538.1 NP_001305467.1 protein sprouty homolog 2
NM_005842.4 NP_005833.1 protein sprouty homolog 2
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12815057 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20736167 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
18070883 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to vascular endothelial growth factor stimulus IDA
IDA: Inferred from direct assay
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
20489163 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24177325 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
20736167 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
17974561 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IDA
IDA: Inferred from direct assay
21536891 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20489163 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18070883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRY2 Protein Structure

Sprouty

Sprouty: Sprouty protein (Spry) (183 - 294)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

protein sprouty homolog 2

SPRY2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410 25416956
Intra
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410 25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411 25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411 25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411 25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370 25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370 25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370 25416956
Intra
SPRY2 O43597 KRTAP9-4 Homo sapiens Q9BYQ2 25416956
Intra
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412 25416956
Intra
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412 25416956
Intra
SPRY2 O43597 RUNX1T1 Homo sapiens Q06455-4 25416956
Intra
SPRY2 O43597 PTGER3 Homo sapiens P43115-12 25416956
Intra
SPRY2 O43597 PTGER3 Homo sapiens P43115-12 25416956
Intra
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6 25416956
Intra
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6 25416956
Intra
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8 25416956
Intra
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8 25416956
Intra
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0 25416956
Intra
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0 25416956
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3 25416956
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3 29892012
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3 31515488
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3 25416956
Intra
SPRY2 O43597 LCE4A Homo sapiens Q5TA78 25416956
Intra
SPRY2 O43597 LCE4A Homo sapiens Q5TA78 25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82 25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82 25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82 25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9 25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9 25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9 25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5 25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5 25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5 25416956
Intra
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4 25416956
Intra
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4 25416956
Intra
SPRY2 O43597 PRKAB2 Homo sapiens O43741 25416956
Intra
SPRY2 O43597 PRKAB2 Homo sapiens O43741 25416956
Intra
SPRY2 O43597 UBASH3B Homo sapiens Q8TF42 25416956
Intra
SPRY2 O43597 GP9 Homo sapiens P14770 25416956
Intra
SPRY2 O43597 GP9 Homo sapiens P14770 25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075 25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075 25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H
21516116
Intra
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8 25416956
Intra
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8 25416956
Intra
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6 25416956
Intra
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6 25416956
Intra
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0 25416956
Intra
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0 25416956
Intra
SPRY2 O43597 SH3KBP1 Homo sapiens Q96B97 15962011
Intra
SPRY2 O43597 SPRY1 Homo sapiens O43609 25416956
Intra
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371 25416956
Intra
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371 25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573 25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573 25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573 25416956
Intra
SPRY2 O43597 GRB2 Homo sapiens P62993 16893902
Intra
SPRY2 O43597 GRB2 Homo sapiens P62993 16893902
Intra
SPRY2 O43597 GNE Homo sapiens Q9Y223 25416956
Intra
SPRY2 O43597 GNE Homo sapiens Q9Y223 25416956
Intra
SPRY2 O43597 CBL Homo sapiens P22681 18273061
Intra
SPRY2 O43597 CBL Homo sapiens P22681 16893902
Intra
SPRY2 O43597 CBL Homo sapiens P22681
ITC
18273061
Intra
SPRY2 O43597 CBL Homo sapiens P22681 15962011
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5 25416956
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5 25416956
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5 33961781
Intra
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2 25416956
Intra
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2 25416956
Intra
SPRY2 O43597 NCK2 Homo sapiens O43639 25416956
Intra
SPRY2 O43597 NCK2 Homo sapiens O43639 25416956
Intra
SPRY2 O43597 MDFI Homo sapiens Q99750 25416956
Intra
SPRY2 O43597 MDFI Homo sapiens Q99750 25416956
Intra
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66 16189514
Intra
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66 25416956
Intra
SPRY2 O43597 GRAP2 Homo sapiens O75791 25416956
Intra
SPRY2 O43597 GRAP2 Homo sapiens O75791 25416956
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242
Y2H
21516116
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242 25416956
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242 25416956
Intra
SPRY2 O43597 ZNF417 Homo sapiens Q8TAU3 25416956
Intra
SPRY2 O43597 AQP1 Homo sapiens P29972 25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1 25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1 25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1 25416956
Intra
SPRY2 O43597 MEOX2 Homo sapiens P50222 25416956
Intra
SPRY2 O43597 STK16 Homo sapiens O75716 25416956
Intra
SPRY2 O43597 STK16 Homo sapiens O75716 25416956
Intra
SPRY2 O43597 TCAF1 Homo sapiens Q9Y4C2 25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6 25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6 25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6 25416956
Intra
SPRY2 O43597 MAPKBP1 Homo sapiens O60336 25416956
Intra
SPRY2 O43597 MAPKBP1 Homo sapiens O60336 25416956
Intra
SPRY2 O43597 CHRD Homo sapiens Q9H2X0 25416956
Intra
SPRY2 O43597 CHRD Homo sapiens Q9H2X0 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

SPRY2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81859 Sprouty 2 Antibody (YA1604) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Iga Nephropathy 3
  • Iga Nephropathy, Susceptibility To, 3

  • IGAN3

  • {Iga Nephropathy, Susceptibility To, 3}

Adrenal Cortical Adenocarcinoma
  • Adrenal Cortex Adenocarcinoma

  • Adrenocortical Carcinoma

Focal Segmental Glomerulosclerosis 3
  • FSGS3

  • Focal Segmental Glomerulosclerosis 3, Susceptibility To

  • Glomerulosclerosis, Focal Segmental, 3

  • Glomerulosclerosis, Focal Segmental, 3, Susceptibility To

  • Glomerulosclerosis, Segmental, Focal, Type 3, Susceptibility To

Legius Syndrome
  • Neurofibromatosis Type 1-Like Syndrome

  • Nfls

  • LGSS

  • Neurofibromatosis 1-Like Syndrome

  • Neurofibromatosis Type 1 Like Syndrome

  • Nf1-Like Syndrome

  • Neurofibromatosis, Type 1-Like Syndrome

Achondroplasia
  • Achondroplastic Dwarfism

  • ACH

  • Osteosclerosis Congenita

  • Achondroplastic Physique

  • Chondrodystrophia

  • Dwarf, Achondroplastic

  • Achondroplastic Short Stature

  • Congenital Osteosclerosis

Lacrimoauriculodentodigital Syndrome
  • Ladd Syndrome

  • Levy-Hollister Syndrome

  • Lacrimo-Auriculo-Dento-Digital Syndrome

  • LADD

  • Lacrimoauriculodento-Digital Syndrome

  • Levy Hollister Syndrome

  • Lard Syndrome

  • Lacrimoauriculoradiodental Syndrome

  • LADDS

  • Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Craniosynostosis
  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis

Cleft Palate, Isolated
  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate

Van Der Woude Syndrome
  • Lip-Pit Syndrome

  • Vws

  • Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip

  • Vdws

  • Lps

  • Lip Pit Syndrome

  • Cleft Lip/Palate With Mucous Cysts Of Lower Lip

  • Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Orofacial Cleft
  • Cleft, Orofacial

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus SPRY2 VGNC VGNC:35242
Mus musculus SPRY2 MGD MGI:1345138
Felis catus SPRY2 VGNC VGNC:65650
Rattus norvegicus SPRY2 RGD RGD:1311472
Macaca mulatta SPRY2 VGNC VGNC:106300
Canis familiaris SPRY2 VGNC VGNC:46766
Others SPRY2 NCBI