SPRY2 - sprouty RTK signaling antagonist 2 Gene
Also Known as IGAN3; hSPRY2
Species: Homo sapiens
About SPRY2
This gene has 2 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues.
Summary
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to Fibroblast Growth Factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on Fibroblast Growth Factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
SPRY2 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001318536.1 | NP_001305465.1 | protein sprouty homolog 2 |
| NM_001318537.1 | NP_001305466.1 | protein sprouty homolog 2 |
| NM_001318538.1 | NP_001305467.1 | protein sprouty homolog 2 |
| NM_005842.4 | NP_005833.1 | protein sprouty homolog 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12815057 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
20736167 | GOA |
| enables protein serine/threonine kinase activator activity |
IMP
IMP: Inferred from mutant phenotype
|
18070883 | GOA |
SPRY2 Protein Structure
Sprouty: Sprouty protein (Spry) (183 - 294)
- 0
- 100
- 200
- 300
- 315 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein sprouty homolog 2 |
|
SPRY2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SPRY2 | O43597 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-5 | Homo sapiens | P60370 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-5 | Homo sapiens | P60370 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-5 | Homo sapiens | P60370 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP9-4 | Homo sapiens | Q9BYQ2 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-11 | Homo sapiens | P60412 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP10-11 | Homo sapiens | P60412 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | RUNX1T1 | Homo sapiens | Q06455-4 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PTGER3 | Homo sapiens | P43115-12 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PTGER3 | Homo sapiens | P43115-12 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | q5jpt6_human | Homo sapiens | Q5JPT6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | q5jpt6_human | Homo sapiens | Q5JPT6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE3C | Homo sapiens | Q5T5A8 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE3C | Homo sapiens | Q5T5A8 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE3E | Homo sapiens | Q5T5B0 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE3E | Homo sapiens | Q5T5B0 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE1B | Homo sapiens | Q5T7P3 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE1B | Homo sapiens | Q5T7P3 | 29892012 | |
|
Intra
|
SPRY2 | O43597 | LCE1B | Homo sapiens | Q5T7P3 | 31515488 | |
|
Intra
|
SPRY2 | O43597 | LCE1B | Homo sapiens | Q5T7P3 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE4A | Homo sapiens | Q5TA78 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE4A | Homo sapiens | Q5TA78 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE2D | Homo sapiens | Q5TA82 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE2D | Homo sapiens | Q5TA82 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LCE2D | Homo sapiens | Q5TA82 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP5-6 | Homo sapiens | Q6L8G9 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP5-6 | Homo sapiens | Q6L8G9 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP5-6 | Homo sapiens | Q6L8G9 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP4-11 | Homo sapiens | Q9BYQ6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP4-11 | Homo sapiens | Q9BYQ6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP4-11 | Homo sapiens | Q9BYQ6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | SHFL | Homo sapiens | Q9NUL5 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | SHFL | Homo sapiens | Q9NUL5 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | SHFL | Homo sapiens | Q9NUL5 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PRKAB2 | Homo sapiens | O43741 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PRKAB2 | Homo sapiens | O43741 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | UBASH3B | Homo sapiens | Q8TF42 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GP9 | Homo sapiens | P14770 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GP9 | Homo sapiens | P14770 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | UBASH3A | Homo sapiens | P57075 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | UBASH3A | Homo sapiens | P57075 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | UBASH3A | Homo sapiens | P57075 | 21516116 | |
|
Intra
|
SPRY2 | O43597 | LONRF1 | Homo sapiens | Q17RB8 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | LONRF1 | Homo sapiens | Q17RB8 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | USP20 | Homo sapiens | Q9Y2K6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | USP20 | Homo sapiens | Q9Y2K6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | TXNDC5 | Homo sapiens | Q86UY0 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | TXNDC5 | Homo sapiens | Q86UY0 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | SH3KBP1 | Homo sapiens | Q96B97 | 15962011 | |
|
Intra
|
SPRY2 | O43597 | SPRY1 | Homo sapiens | O43609 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | EIF4E2 | Homo sapiens | O60573 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | EIF4E2 | Homo sapiens | O60573 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | EIF4E2 | Homo sapiens | O60573 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GRB2 | Homo sapiens | P62993 | 16893902 | |
|
Intra
|
SPRY2 | O43597 | GRB2 | Homo sapiens | P62993 | 16893902 | |
|
Intra
|
SPRY2 | O43597 | GNE | Homo sapiens | Q9Y223 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GNE | Homo sapiens | Q9Y223 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | CBL | Homo sapiens | P22681 | 18273061 | |
|
Intra
|
SPRY2 | O43597 | CBL | Homo sapiens | P22681 | 16893902 | |
|
Intra
|
SPRY2 | O43597 | CBL | Homo sapiens | P22681 | 18273061 | |
|
Intra
|
SPRY2 | O43597 | CBL | Homo sapiens | P22681 | 15962011 | |
|
Intra
|
SPRY2 | O43597 | ZDHHC17 | Homo sapiens | Q8IUH5 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ZDHHC17 | Homo sapiens | Q8IUH5 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ZDHHC17 | Homo sapiens | Q8IUH5 | 33961781 | |
|
Intra
|
SPRY2 | O43597 | HEXIM2 | Homo sapiens | Q96MH2 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | HEXIM2 | Homo sapiens | Q96MH2 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | NCK2 | Homo sapiens | O43639 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | NCK2 | Homo sapiens | O43639 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 16189514 | |
|
Intra
|
SPRY2 | O43597 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GRAP2 | Homo sapiens | O75791 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | GRAP2 | Homo sapiens | O75791 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | OTX1 | Homo sapiens | P32242 | 21516116 | |
|
Intra
|
SPRY2 | O43597 | OTX1 | Homo sapiens | P32242 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | OTX1 | Homo sapiens | P32242 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ZNF417 | Homo sapiens | Q8TAU3 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | AQP1 | Homo sapiens | P29972 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ATRIP | Homo sapiens | Q8WXE1 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ATRIP | Homo sapiens | Q8WXE1 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | ATRIP | Homo sapiens | Q8WXE1 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | STK16 | Homo sapiens | O75716 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | STK16 | Homo sapiens | O75716 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | TCAF1 | Homo sapiens | Q9Y4C2 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PACSIN3 | Homo sapiens | Q9UKS6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PACSIN3 | Homo sapiens | Q9UKS6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | PACSIN3 | Homo sapiens | Q9UKS6 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | MAPKBP1 | Homo sapiens | O60336 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | MAPKBP1 | Homo sapiens | O60336 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | CHRD | Homo sapiens | Q9H2X0 | 25416956 | |
|
Intra
|
SPRY2 | O43597 | CHRD | Homo sapiens | Q9H2X0 | 25416956 |
SPRY2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81859 | Sprouty 2 Antibody (YA1604) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Iga Nephropathy 3 |
|
|
| Adrenal Cortical Adenocarcinoma |
|
|
| Focal Segmental Glomerulosclerosis 3 |
|
|
| Legius Syndrome |
|
|
| Achondroplasia |
|
|
| Lacrimoauriculodentodigital Syndrome |
|
|
| Craniosynostosis |
|
|
| Cleft Palate, Isolated |
|
|
| Van Der Woude Syndrome |
|
|
| Orofacial Cleft |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | SPRY2 | VGNC | VGNC:35242 |
| Mus musculus | SPRY2 | MGD | MGI:1345138 |
| Felis catus | SPRY2 | VGNC | VGNC:65650 |
| Rattus norvegicus | SPRY2 | RGD | RGD:1311472 |
| Macaca mulatta | SPRY2 | VGNC | VGNC:106300 |
| Canis familiaris | SPRY2 | VGNC | VGNC:46766 |
| Others | SPRY2 | NCBI |