ATRIP - ATR interacting protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84126

About ATRIP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,446,737-48,467,645 (from NCBI)

This gene has 9 transcripts (splice variants), 120 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 11.6), thyroid (RPKM 3.8) and 23 other tissues.

Summary

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

ATRIP Products (4)

mRNA	Protein	Name
NM_001271022.2	NP_001257951.1	ATR-interacting protein isoform 3
NM_001271023.2	NP_001257952.1	ATR-interacting protein isoform 4
NM_032166.4	NP_115542.2	ATR-interacting protein isoform 2
NM_130384.3	NP_569055.1	ATR-interacting protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	24332808	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14657349	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATR-ATRIP complex	IPI IPI: Inferred from physical interaction	11721054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATR-interacting protein	ATM and Rad3-related-interacting protein

ATRIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATRIP	Q8WXE1	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	ATRIP	Q8WXE1	MX2	Homo sapiens	P20592	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	MX2	Homo sapiens	P20592	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	PCTK1	Homo sapiens	Q9BRL4	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	CCDC28B	Homo sapiens	Q9BUN5	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	ATRIP	Q8WXE1	MOS	Homo sapiens	P00540	Validated Y2H	25416956
Intra	ATRIP	Q8WXE1	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	CINP	Homo sapiens	Q9BW66	Anti Tag CoIP	19889979
Intra	ATRIP	Q8WXE1	CINP	Homo sapiens	Q9BW66	Y2H	19889979
Intra	ATRIP	Q8WXE1	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	FAM156B	Homo sapiens	Q8NDB6	Validated Y2H	25416956
Intra	ATRIP	Q8WXE1	FAM156B	Homo sapiens	Q8NDB6	Y2H Array	25416956
Intra	ATRIP	Q8WXE1	FAM156B	Homo sapiens	Q8NDB6	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	METTL21A	Homo sapiens	Q8WXB1	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	ATRIP	Q8WXE1	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	ATRIP	Q8WXE1	ATR	Homo sapiens	Q13535	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

ATRIP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83220	ATRIP Antibody (YA2965)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Aicardi-Goutieres Syndrome 1	AGS1 Ags Cree Encephalitis Pseudotoxoplasmosis Syndrome Aicardi-Goutieres Syndrome 1, Dominant And Recessive Pseudo-Torch Syndrome Encephalopathy, Familial Infantile, With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Autosomal Dominant Aicardi-Goutieres Syndrome Encephalopathy Familial Infantile With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome, Type 1, Dominant And Recessive Aicardi-Goutieres Syndrome 5
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Seckel Syndrome 1	SCKL1 Nanocephalic Dwarfism Microcephalic Primordial Dwarfism I Seckel-Type Dwarfism Bird-Headed Dwarfism Sckl Seckel Syndrome, Type 1 Seckel Syndrome
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Thrombotic Microangiopathy	Tma
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1	Cadasil Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Casil Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Familial Vascular Leukoencephalopathy CADASIL1 Cadasil 1 Hereditary Multi-Infarct Dementia Cadasil Syndrome Dementia, Hereditary Multiinfarct Type Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1 Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy Dementia, Hereditary Multi-Infarct Type Hereditary Dementia, Multi-Infarct Type Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1 Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant Dementia Hereditary Multiinfarct Type Dementia Hereditary Multi-Infarct Type Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Familial Chilblain Lupus
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Autosomal Recessive Cerebellar Ataxia	Arca
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157941	ART0380	Inhibitor	99.90%	Unkown
HY-RS01249	ATRIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22401	Atrip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28925	Atrip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATRIP	VGNC	VGNC:49885
Macaca mulatta	ATRIP	VGNC	VGNC:84235
Mus musculus	ATRIP	MGD	MGI:1925349
Bos taurus	ATRIP	VGNC	VGNC:50170
Felis catus	ATRIP	VGNC	VGNC:69356
Others	ATRIP	NCBI