MX2 - MX dynamin like GTPase 2 Gene

Also Known as MXB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4600

About MX2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,362,027-41,409,393 (from NCBI)

This gene has 18 transcripts (splice variants), 102 orthologues and 6 paralogues. Broad expression in spleen (RPKM 16.5), appendix (RPKM 13.6) and 23 other tissues.

Summary

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the Dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the Antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

MX2 Products (1)

mRNA	Protein	Name
NM_002463.2	NP_002454.1	interferon-induced GTP-binding protein Mx2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	15184662	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	24121441	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15184662	GOA
involved in regulation of nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	15184662	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	24121441	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	24048477	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of nuclear pore	IDA IDA: Inferred from direct assay	15184662	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MX2 Protein Structure

Dynamin_N

Dynamin_M

GED

0
200
400
600
715 a.a.

Protein Preferred Names	Protein Names
interferon-induced GTP-binding protein Mx2	interferon-regulated resistance GTP-binding protein MXB

MX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MX2	P20592	EHMT2	Homo sapiens	A2ABF9	Validated Y2H	25416956
Intra	MX2	P20592	EHMT2	Homo sapiens	A2ABF9	Y2H Prey Pooling	25416956
Intra	MX2	P20592	PIAS2	Homo sapiens	O75928	Validated Y2H	25416956
Intra	MX2	P20592	PIAS2	Homo sapiens	O75928	Y2H Prey Pooling	25416956
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Validated Y2H	32296183
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
Intra	MX2	P20592	ATRIP	Homo sapiens	Q8WXE1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

MX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810900	MX2 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Pediculus Humanus Corporis Infestation	Body Louse Infestation Pediculus Corporis Pediculus Humanus Infestation
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18051	CXL 017		/	Unkown
HY-RS08860	MX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106289	Antibiotic MX 2		/	Unkown
HY-N14477	Saframycin Mx2	Inhibitor	/	Unkown
HY-RS18119	Mx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24593	Mx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MX2	VGNC	VGNC:43512
Macaca mulatta	MX2	VGNC	VGNC:81723
Bos taurus	MX2	VGNC	VGNC:50221
Others	MX2	NCBI