EHMT2 - euchromatic histone lysine methyltransferase 2 Gene

Also Known as G9A; BAT8; GAT8; NG36; KMT1C; C6orf30

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10919

About EHMT2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,879,759-31,897,698 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 210 orthologues and 19 paralogues. Ubiquitous expression in ovary (RPKM 14.8), testis (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each Other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

EHMT2 Products (13)

mRNA	Protein	Name
XM_006714975.2	XP_006715038.2	histone-lysine N-methyltransferase EHMT2 isoform X2
NM_001395164.1	NP_001382093.1	histone-lysine N-methyltransferase EHMT2 isoform j
NM_006709.5	NP_006700.3	histone-lysine N-methyltransferase EHMT2 isoform a
NM_001395163.1	NP_001382092.1	histone-lysine N-methyltransferase EHMT2 isoform i
NM_001395160.1	NP_001382089.1	histone-lysine N-methyltransferase EHMT2 isoform f
NM_025256.7	NP_079532.5	histone-lysine N-methyltransferase EHMT2 isoform b
NM_001363689.2	NP_001350618.1	histone-lysine N-methyltransferase EHMT2 isoform e
NM_001395162.1	NP_001382091.1	histone-lysine N-methyltransferase EHMT2 isoform h
NM_001289413.2	NP_001276342.1	histone-lysine N-methyltransferase EHMT2 isoform c
NM_001395165.1	NP_001382094.1	histone-lysine N-methyltransferase EHMT2 isoform k
XM_006714974.2	XP_006715037.2	histone-lysine N-methyltransferase EHMT2 isoform X1
NM_001395161.1	NP_001382090.1	histone-lysine N-methyltransferase EHMT2 isoform g
NM_001318833.2	NP_001305762.1	histone-lysine N-methyltransferase EHMT2 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	16702210	GOA
enables histone H3K56 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	22387026	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	20118233	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	23918802	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	19144645	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to starvation	IDA IDA: Inferred from direct assay	23918802	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19144645	GOA
involved in peptidyl-lysine dimethylation	IDA IDA: Inferred from direct assay	20118233	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	22387026	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	19144645	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19144645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHMT2 Protein Structure

Ank_2

Pre-SET

SET

0
200
400
600
800
1000
1210 a.a.

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase EHMT2	G9A histone methyltransferase H3-K9-HMTase 3 HLA-B associated transcript 8 ankyrin repeat-containing protein euchromatic histone-lysine N-methyltransferase 2 histone H3-K9 methyltransferase 3 histone-lysine N-methyltransferase, H3 lysine-9 specific 3 lysine N-methyltransferase 1C

EHMT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EHMT2	Q96KQ7	KDM1A	Homo sapiens	O60341-1	Anti Bait CoIP	26751641
Intra	EHMT2	Q96KQ7	MTA2	Homo sapiens	O94776	Anti Bait CoIP	26028330
Intra	EHMT2	Q96KQ7	MTA2	Homo sapiens	O94776	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	MTA3	Homo sapiens	Q9BTC8	Anti Bait CoIP	26028330
Intra	EHMT2	Q96KQ7	MTA3	Homo sapiens	Q9BTC8	CH-IP	26028330
Intra	EHMT2	Q96KQ7	MTA3	Homo sapiens	Q9BTC8	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	EHMT2	Q96KQ7	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	16287849
Intra	EHMT2	Q96KQ7	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	26028330
Intra	EHMT2	Q96KQ7	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	24492005
Intra	EHMT2	Q96KQ7	GATA3	Homo sapiens	P23771	Anti Bait CoIP	26028330
Intra	EHMT2	Q96KQ7	GATA3	Homo sapiens	P23771	CH-IP	26028330
Intra	EHMT2	Q96KQ7	GATA3	Homo sapiens	P23771	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	MTA1	Homo sapiens	Q13330	Anti Bait CoIP	26028330
Intra	EHMT2	Q96KQ7	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	EHMT2	Q96KQ7	PLOD3	Homo sapiens	O60568	Anti Tag CoIP	26028330
Intra	EHMT2	Q96KQ7	PRRC2B	Homo sapiens	Q5JSZ5	Y2H Pooling	16189514
Intra	EHMT2	Q96KQ7	KLF12	Homo sapiens	Q9Y4X4	Y2H Pooling	16189514
Intra	EHMT2	Q96KQ7	KLF12	Homo sapiens	Q9Y4X4	Validated Y2H	32296183
Intra	EHMT2	Q96KQ7	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	18953337
Intra	EHMT2	Q96KQ7	EPDR1	Homo sapiens	Q9UM22	Validated Y2H	32296183
Intra	EHMT2	Q96KQ7	GFI1	Homo sapiens	Q99684	Anti Bait CoIP	16287849
Cross	EHMT2	Q96KQ7	Gfi1	Rattus norvegicus	Q07120	Anti Bait CoIP	16287849
Cross	EHMT2	Q96KQ7	Gfi1	Rattus norvegicus	Q07120	Anti Tag CoIP	16287849

Cross: Cross-species interaction Intra: Intraspecies interaction

EHMT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82628	EHMT2 Antibody (YA2373)	WB, IHC-P	Human
HY-P84734	EHMT2 Antibody (YA4431)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84734A	EHMT2 Antibody (YA4431)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Prader-Willi Syndrome Due To Imprinting Mutation Upd(15)Mat
Primary Hyperoxaluria	Hyperoxaluria, Primary Oxalosis Hyperoxaluria Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Kleefstra Syndrome	9q34.3 Microdeletion Syndrome 9q Subtelomeric Deletion Syndrome 9q- Syndrome Chromosome 9q Deletion Syndrome 9qstds Chromosome 9q34.3 Deletion Syndrome 9q34.3 Deletion Syndrome Chromosome 9, Trisomy 9q
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf
Basan Syndrome	Adermatoglyphia With Congenital Facial Milia And Acral Blisters, Digital Contractures, And Nail Abnormalities Ectodermal Dysplasia, Absent Dermatoglyphic Pattern, Changes In Nails, And Simian Crease Baird Syndrome Absence Of Fingerprints Congenital Milia Absence Of Dermatoglyphics Congenital Milia Absence Of Fingerprints-Congenital Milia Syndrome Absence Of Dermatoglyphics-Congenital Milia Syndrome Basan-Baird Syndrome BSNS Adermatoglyphia, Congenital Facial Milia, Acral Blisters, Digital Contractures, Nail Abnormalities
Kleefstra Syndrome 1	9q Subtelomeric Deletion Syndrome KLEFS1 Chromosome 9q34.3 Deletion Syndrome 9q- Syndrome 9q34 Deletion Syndrome Kleefstra Syndrome Due To 9q34 Microdeletion Kleefstra Syndrome 9q-Syndrome 9qstds Kleefstra Syndrome Due To 9q Subtelomeric Deletion Kleefstra Syndrome Due To Del(9)(Q34) Kleefstra Syndrome Due To Monosomy 9q34 Chromosome 9q Subtelomeric Deletion Syndrome Kleefstra Syndrome, Type 1
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16705	BRD4770	Inhibitor	99.79%	Unkown
HY-111778	EHMT2-IN-1	Inhibitor	99.85%	Unkown
HY-161759	MS152	Inhibitor	99.36%	Unkown
HY-111904	EHMT2-IN-2	Inhibitor	99.0%	Unkown
HY-183058	EZM8266	Inhibitor	98.24%	Unkown
HY-15647	BRD9539	Inhibitor	99.73%	Unkown
HY-44062	G9a-IN-1	Inhibitor	98.12%	Unkown
HY-133031	CSV0C018875	Inhibitor	/	Unkown
HY-133031A	CSV0C018875 hydrochloride	Inhibitor	/	Unkown
HY-183602	FRC-303	Inhibitor	/	Unkown
HY-183603	FRC-222	Inhibitor	/	Unkown
HY-RS04230	EHMT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04231	Ehmt2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04232	Ehmt2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EHMT2	VGNC	VGNC:72041
Bos taurus	EHMT2	VGNC	VGNC:50609
Rattus norvegicus	EHMT2	RGD	RGD:1302972
Felis catus	EHMT2	VGNC	VGNC:61767
Canis familiaris	EHMT2	VGNC	VGNC:49100
Mus musculus	EHMT2	MGD	MGI:2148922
Others	EHMT2	NCBI