GATA3 - GATA binding protein 3 Gene

Also Known as HDR; HDRS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2625

About GATA3

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:8,045,333-8,075,198 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 7 paralogues and is associated with 89 phenotypes. Biased expression in skin (RPKM 54.6), urinary bladder (RPKM 20.0) and 7 other tissues.

Summary

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial Cell Biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]

GATA3 Products (2)

mRNA	Protein	Name
NM_001002295.2	NP_001002295.1	trans-acting T-cell-specific transcription factor GATA-3 isoform 1
NM_002051.3	NP_002042.1	trans-acting T-cell-specific transcription factor GATA-3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	2017177	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19232384	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19674970	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20484083	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	19674970	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	20855495	GOA
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	18445004	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19674970	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15016828	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19232384	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15662016	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19723756	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell differentiation	IDA IDA: Inferred from direct assay	2017177	GOA
involved in T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	20484083	GOA
involved in cellular response to interferon-alpha	IEP IEP: Inferred from expression pattern	20554961	GOA
involved in cellular response to interleukin-4	IEP IEP: Inferred from expression pattern	20554961	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	19674970	GOA
involved in ear development	IMP IMP: Inferred from mutant phenotype	19248180	GOA
involved in kidney development	IMP IMP: Inferred from mutant phenotype	19248180	GOA
involved in lymphocyte migration	IDA IDA: Inferred from direct assay	19805038	GOA
involved in mesenchymal to epithelial transition	IDA IDA: Inferred from direct assay	20189993	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20189993	GOA
involved in negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	20189993	GOA
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19674970	GOA
acts upstream of negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	26451614	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in negative regulation of mammary gland epithelial cell proliferation	IDA IDA: Inferred from direct assay	19483726	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19723756	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in positive regulation of interleukin-13 production	IDA IDA: Inferred from direct assay	20554961	GOA
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	20368097	GOA
involved in positive regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	20554961	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	26451614	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	19674970	GOA
involved in positive regulation of thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	19248180	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2017177	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2017177	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of transcription regulatory region DNA binding	IMP IMP: Inferred from mutant phenotype	20368097	GOA
involved in regulation of cellular response to X-ray	IMP IMP: Inferred from mutant phenotype	19735555	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	10037815	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	20583921	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20855495	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19674970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GATA3 Protein Structure

GATA

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
trans-acting T-cell-specific transcription factor GATA-3	GATA-binding factor 3

GATA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GATA3	P23771	GCM1	Homo sapiens	Q9NP62	Anti Tag CoIP	26899996
Intra	GATA3	P23771	GCM1	Homo sapiens	Q9NP62	Pull Down	26899996
Intra	GATA3	P23771	MTA3	Homo sapiens	Q9BTC8	Pull Down	26028330
Intra	GATA3	P23771	MTA3	Homo sapiens	Q9BTC8	CH-IP	26028330
Intra	GATA3	P23771	MTA3	Homo sapiens	Q9BTC8	Anti Bait CoIP	26028330
Intra	GATA3	P23771	MTA3	Homo sapiens	Q9BTC8	Anti Tag CoIP	26028330
Intra	GATA3	P23771	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	GATA3	P23771	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	GATA3	P23771	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	GATA3	P23771	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	GATA3	P23771	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	GATA3	P23771	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	GATA3	P23771	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	GATA3	P23771	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	GATA3	P23771	TBX21	Homo sapiens	Q9UL17	Anti Tag CoIP	17075044
Intra	GATA3	P23771	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	17075044
Intra	GATA3	P23771	HDAC3	Homo sapiens	O15379	Anti Bait CoIP	17075044
Intra	GATA3	P23771	HDAC5	Homo sapiens	Q9UQL6	Anti Bait CoIP	17075044
Intra	GATA3	P23771	EHMT2	Homo sapiens	Q96KQ7	CH-IP	26028330
Intra	GATA3	P23771	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	26028330
Intra	GATA3	P23771	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	26028330
Intra	GATA3	P23771	EHMT2	Homo sapiens	Q96KQ7	Pull Down	26028330

Cross: Cross-species interaction Intra: Intraspecies interaction

GATA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82754	GATA3 Antibody (YA2499)	WB, IHC-P, ICC/IF, ChIP, FC	Human
HY-P82848	Phospho-GATA3 (Ser308) Antibody (YA2593)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82848A	Phospho-GATA3 (Ser308) Antibody (YA2593)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P83022	GATA2/3 Antibody (YA2767)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P84200	GATA3 Antibody (YA3897)	WB, IHC-P, FC, ELISA	Human
HY-P84200A	GATA3 Antibody (YA3897)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome	Barakat Syndrome Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Hdr Syndrome Nephrosis, Nerve Deafness, And Hypoparathyroidism Hypoparathyroidism, Sensorineural Deafness, And Renal Disease HDR HDRS Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome Hypoparathyroidism-Sensorineural Hearing Loss-Renal Disease Syndrome Nephrosis Nephrotic Syndrome
Hypoparathyroidism-Deafness-Renal Disease Syndrome	Barakat Syndrome Hypoparathyroidism, Deafness, Renal Disease Syndrome Hdr Syndrome Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Renal Dysplasia	Kidney Dysplasia Renal Cell Dysplasia Congenital Renal Dysplasia Dysplasia Of Kidney Dysplastic Kidney
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Colitis
Sweat Gland Cancer	Sweat Gland Carcinoma Malignant Neoplasm Of Sweat Gland Malignant Tumor Of The Sweat Gland Carcinoma Of The Sweat Gland Primary Malignant Neoplasm Of Sweat Gland Sweat Gland Neoplasms
Inverted Transitional Papilloma	Transitional Papilloma, Inverted Transitional Cell Papilloma, Inverted
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Ureteral Benign Neoplasm	Neoplasm Of Ureter Ureteral Tumor Cancer Of The Ureter Malignant Tumour Of Ureter Ureteric Cancer Primary Malignant Neoplasm Of Ureter
Filariasis	Disease Due To Superfamily Filarioidea Bancroftian Filarial Fever Mumu Wanganga Bancroftian Filariasis Wuchereriosis Brugiosis Malayan Filariasis
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Mucinous Cystadenofibroma
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Cervical Serous Adenocarcinoma
Rhinitis	Runny Nose
Wolffian Duct Adenocarcinoma	Cervical Mesonephric Adenocarcinoma
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Breast Lobular Carcinoma	Cancer, Breast, Lobular Lobular Breast Carcinoma
Ovarian Brenner Tumor	Benign Ovarian Brenner Tumor Brenner Tumor Benign Ovarian Brenner Tumour Ovarian Brenner Tumour Brenner Tumor Of Ovary Benign Brenner Tumor
Bladder Adenocarcinoma	Adenocarcinoma Of Bladder Adenocarcinoma Of The Urinary Bladder Bladder Adenocarcinoma, Not Otherwise Specified Adenocarcinoma Bladder
Apocrine Adenocarcinoma	Apocrine Carcinoma Apocrine Gland Carcinoma Carcinoma Of The Apocrine Gland Carcinoma Of Apocrine Gland
Water-Clear Cell Adenoma
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Chronic Asthma
Prostatic Urethral Cancer
Nephrogenic Adenoma	Nephrogenic Metaplasia
Dermatitis, Atopic, 8	ATOD8 Atopic Dermatitis 8 Dermatitis, Atopic, Severity Of Dermatitis, Atopic, Susceptibility To, 8 Dermatitis, Atopic 8
Gastric Diffuse Adenocarcinoma	Diffuse Gastric Adenocarcinoma Carcinoma, Diffuse Type
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Breast Mucinous Carcinoma	Mucinous Carcinoma Of Breast Invasive Mucinous Breast Carcinoma
Respiratory Allergy	Airway Allergy
Microinvasive Cervical Squamous Cell Carcinoma	Early Invasive Cervical Squamous Cell Carcinoma
Linitis Plastica	Leather-Bottle Stomach
Bartholin'S Gland Adenocarcinoma	Bartholin Gland Adenocarcinoma Adenocarcinoma Of Bartholin'S Gland Adenocarcinoma Of The Bartholin'S Gland
Sebaceous Breast Carcinoma
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Ureter Squamous Cell Carcinoma	Ureteral Epidermoid Carcinoma
Wolffian Duct Adenoma	Benign Mesonephroma Mesonephric Adenoma Mesonephroma, Benign Fatwo Female Adnexal Tumor Of Probable Wolffian Origin Wat Wolffian Adenoma Wolffian Adnexal Tumor Wolffian Tumor
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Aneruptive Fever	Rickettsia Helvetica Spotted Fever
Hypertrophy Of Breast	Breasts Enlarged Large Breast Hypertrophy Of Breast Nos Hypertrophy Of Male Breast Hypertrophic Breast Excessive Development Of Breast Macromastia Mastoplastia
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Psoriasis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Breast Hemangioma	Angioma Of The Breast Hemangioma Of Breast Haemangioma Of Breast
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Ciliary Dyskinesia, Primary, 5	Primary Ciliary Dyskinesia 5 CILD5 Ciliary Dyskinesia, Primary, 5, Without Situs Inversus Primary Ciliary Dyskinesia 5 Without Situs Inversus Ics5 Immotile Cilia Syndrome 5 Primary Ciliary Dyskinesia 5 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 5
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Endocervical Carcinoma	Carcinoma Of Endocervix Carcinoma Of The Endocervix
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Sigmoid Disease	Sigmoid Diseases
In Situ Carcinoma	Carcinoma In Situ
Lung Combined Large Cell Neuroendocrine Carcinoma	Combined Large Cell Neuroendocrine Carcinoma Of Lung Pulmonary Combined Large Cell Neuroendocrine Carcinoma Combined Large Cell Lung Neuroendocrine Carcinoma
Urinary Bladder Small Cell Neuroendocrine Carcinoma	Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Pre-Malignant Neoplasm
Ureter Small Cell Carcinoma	Ureteral Small Cell Carcinoma
Endocervical Adenocarcinoma	Endocervical Carcinoma
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Dermatitis, Atopic, 5	ATOD5 Atopic Dermatitis 5 Dermatitis, Atopic, Susceptibility To, 5 Dermatitis, Atopic 5
Cystic Basal Cell Carcinoma	Skin Cystic Basal Cell Carcinoma
Chromosomal Deletion Syndrome
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Retinal Melanoma	Malignant Retinal Melanoma Malignant Melanoma Of Retina
Male Urethral Cancer	Male Urethral Malignant Neoplasm
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Papillary Adenofibroma
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138113	Pyrrothiogatain	Inhibitor	98.61%	Unkown
HY-N4087	Platycodin D2	Inducer	99.84%	Unkown
HY-N0407	Picroside I	Inhibitor	99.31%	Unkown
HY-185206	BSJ-05-037		99.83%	Unkown
HY-114495	Caerulomycin A	Inhibitor	98.0%	Unkown
HY-N0600	Ginsenoside F3		99.84%	Unkown
HY-RS05291	GATA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174675	Human GATA3 mRNA		/	Unkown
HY-RS17910	Gata3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24379	Gata3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GATA3	MGD	MGI:95663
Bos taurus	GATA3	VGNC	VGNC:29267
Macaca mulatta	GATA3	VGNC	VGNC:72889
Rattus norvegicus	GATA3	RGD	RGD:621250
Canis familiaris	GATA3	VGNC	VGNC:41123
Others	GATA3	NCBI