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Phospho-GATA3 (Ser308) Antibody (YA2593)

(Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3)
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Phospho-GATA3 (Ser308) Antibody (YA2593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-GATA3 (Ser308).

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • Phospho-GATA3 (Ser308) Antibody (YA2593) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50-1:100 1:20

Product Details

Description

Phospho-GATA3 (Ser308) Antibody (YA2593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-GATA3 (Ser308).

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 48 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 48 kDa
Species Reactivity Database

Entrez Gene: 2625 Human

SwissProt: P23771 Human

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser308 of human GATA3

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Phosphorylated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GATA3 transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:T cells and endothelial cells

  • Isoforms & Post-Translational Modification

    P23771 has 2 isomers: P23771-1: 47916 Da (predicted); P23771-2: 48045 Da (predicted).

  • Subunit

    Interacts with TBX21 ('Tyr-530' phosphorylated form)

  • SwissProt ID

    P23771

  • Gene ID
    2625 [NCBI]
  • Synonyms

    GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

  • Research Field

    Immunology

Phospho-GATA3 (Ser308) Antibody (YA2593) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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