TBX21 - T-box transcription factor 21 Gene

Also Known as TBET; IMD88; T-PET; T-bet; TBLYM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30009

About TBX21

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,733,236-47,746,122 (from NCBI)

This gene has 2 transcripts (splice variants), 305 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in spleen (RPKM 4.5), bone marrow (RPKM 4.1) and 12 other tissues.

Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

TBX21 Products (1)

mRNA	Protein	Name
NM_013351.2	NP_037483.1	T-box transcription factor TBX21

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18504404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15662016	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19805038	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lymphocyte migration	IDA IDA: Inferred from direct assay	19805038	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18504404	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19805038	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	20583921	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBX21 Protein Structure

T-box

0
100
200
300
400
500
535 a.a.

Protein Preferred Names	Protein Names
T-box transcription factor TBX21	T-box 21

TBX21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TBX21	Q9UL17	SP1	Homo sapiens	P08047	Anti Bait CoIP	17075044
Intra	TBX21	Q9UL17	SP1	Homo sapiens	P08047	Anti Tag CoIP	17075044
Intra	TBX21	Q9UL17	EP300	Homo sapiens	Q09472	Anti Bait CoIP	17075044
Intra	TBX21	Q9UL17	EP300	Homo sapiens	Q09472	Anti Tag CoIP	17075044
Intra	TBX21	Q9UL17	GATA3	Homo sapiens	P23771	Anti Bait CoIP	17075044
Intra	TBX21	Q9UL17	GATA3	Homo sapiens	P23771	Anti Tag CoIP	17075044
Intra	TBX21	Q9UL17	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	17075044
Intra	TBX21	Q9UL17	CREBBP	Homo sapiens	Q92793	Anti Tag CoIP	17075044

Cross: Cross-species interaction Intra: Intraspecies interaction

TBX21 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81472	T-bet / Tbx21 Antibody (YA1217)	IHC-P	Human
HY-P81472A	T-bet / Tbx21 Antibody (YA1217)(PBS only)	IHC-P	Human
HY-P81757	T-bet / Tbx21 Antibody (YA1502)	IHC-P, FC	Human
HY-P85868	T-bet / Tbx21 Antibody (YA5560)	WB, ICC/IF, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Asthma, Nasal Polyps, And Aspirin Intolerance	Asthma And Nasal Polyps Asa Triad Asthma, Aspirin-Induced, Susceptibility To Asthma, Aspirin-Induced Asthma, With Nasal Polyps And Aspirin Intolerance ANPAI Aia Aspirin-Intolerant Asthma Asthma Aspirin-Induced Nasal Polyps Asthma And Aspirin Sensitivity Samter Triad Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Immunodeficiency 88	IMD88 Immunodeficiency 88, Mycobacteriosis, Autosomal Recessive
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Aneruptive Fever	Rickettsia Helvetica Spotted Fever
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Uveitis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Autoimmune Myocarditis
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Respiratory Allergy	Airway Allergy
Listeriosis	Listeria Infection Infection By Listeria Monocytogenes Listeria Monocytogenes Infection Listeria Infections Listerial Foodborne Infection Circling Disease Infection Due To Listeria Monocytogenes Listerellosis
Chronic Asthma
Salmonellosis	Salmonella Infections Salmonella Infection
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Autoimmune Disease Of Central Nervous System
Dermatitis, Atopic, 5	ATOD5 Atopic Dermatitis 5 Dermatitis, Atopic, Susceptibility To, 5 Dermatitis, Atopic 5
Autoimmune Disease Of Gastrointestinal Tract
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Gastrointestinal Tularemia	Enteric Tularemia Intestinal Tularaemia
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21062	Tbx21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14277	TBX21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27579	Tbx21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TBX21	RGD	RGD:1308264
Mus musculus	TBX21	MGD	MGI:1888984
Bos taurus	TBX21	VGNC	VGNC:35668
Felis catus	TBX21	VGNC	VGNC:66005
Macaca mulatta	TBX21	VGNC	VGNC:78271
Canis familiaris	TBX21	VGNC	VGNC:47173
Others	TBX21	NCBI