HDAC3 - histone deacetylase 3 Gene

Homo sapiens

Also known as HD3; RPD3; KDAC3; RPD3-2

Gene ID: 8841 | Gene type: protein coding

About HDAC3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,620,881-141,636,849 (from NCBI)

This gene has 16 transcripts (splice variants), 155 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and Apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

HDAC3 Products(10)

mRNA	Protein	Name
NR_149169.2
NM_001355041.2	NP_001341970.1	histone deacetylase 3 isoform 4
NR_149167.2
NM_001355040.2	NP_001341969.1	histone deacetylase 3 isoform 3
NR_149166.2
NR_149164.2
NM_003883.4	NP_003874.2	histone deacetylase 3 isoform 2
NR_149168.2
NR_149165.2
NM_001355039.2	NP_001341968.1	histone deacetylase 3 isoform 1

HDAC3 Protein Structure

Hist_deacetyl

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 3

SMAP45	protein deacetylase HDAC3
protein deacylase HDAC3

Recombinant HDAC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75147	HDAC3 Protein, Human (sf9, His-GST)	O15379 (M1-I428)	≥95%

Related Diseases

Diseases

Alias

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10221	Vorinostat	Inhibitor	99.95%	Yes
HY-109015	Tucidinostat	Inhibitor	98.70%	Unkown
HY-12164	Mocetinostat	Inhibitor	99.43%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12163	Entinostat	Inhibitor	99.65%	Phase 3
HY-50934	Tacedinaline	Inhibitor	99.55%	Phase 3
HY-10990	Abexinostat	Inhibitor	98.61%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842	Givinostat	Inhibitor	98.05%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	/	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-100748	Zabadinostat	Inhibitor	99.81%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.28%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-14718A	Resminostat hydrochloride	Inhibitor	99.68%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.42%	Phase 2
HY-14718	Resminostat	Inhibitor	/	Phase 2
HY-10223	CUDC-101	Inhibitor	99.19%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1

Pre-clinical Phase

Bioactive Molecules (89)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13909	RGFP966	Inhibitor	99.81%	Unkown
HY-13428	Tubacin	Inhibitor	95.50%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-16699	Nexturastat A	Inhibitor	99.03%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-100719	BRD-6929	Inhibitor	99.04%	Unkown
HY-16425	RG2833	Inhibitor	99.86%	Unkown
HY-19618	BRD3308	Inhibitor	98.82%	Unkown
HY-104008	ACY-957	Inhibitor	99.87%	Unkown
HY-115475	SW-100	Inhibitor	99.59%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.39%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.64%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-153358	TNG260	Inhibitor	99.91%	Unkown
HY-19328	ACY-775	Inhibitor	99.83%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-W009776	Suberoyl bis-hydroxamic acid	Inhibitor	≥98.0%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-18712	BG45	Inhibitor	99.96%	Unkown
HY-13267	Droxinostat	Inhibitor	98.91%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-100384	NKL 22	Inhibitor	97.27%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-119017	SB-429201	Inhibitor	98.99%	Unkown
HY-114483	AES-135	Inhibitor	98.21%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-138831	AES-350	Inhibitor	98.02%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-124053	BRD2492	Inhibitor	99.18%	Unkown
HY-146346	HD-TAC7	Inhibitor	98.45%	Unkown
HY-102083	BRD4884	Inhibitor	≥99.0%	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-149669	PH14	Inhibitor	98.23%	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-161154	HDAC3-IN-3	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-152174	HDAC-IN-52	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-153583	HDAC8-IN-4	Inhibitor	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-117374	HDAC3-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-154855	HDAC-IN-56	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	/	Unkown
HY-147840	HDAC-IN-41	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-150774	HDAC6/HSP90-IN-2	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HDAC3	VGNC	VGNC:67549
Canis familiaris	HDAC3	VGNC	VGNC:50628
Rattus norvegicus	HDAC3	RGD	RGD:619977
Mus musculus	HDAC3	MGD	MGI:1343091
Bos taurus	HDAC3	VGNC	VGNC:106764
Macaca mulatta	HDAC3	VGNC	VGNC:73359

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