HDAC3 - histone deacetylase 3 Gene

Also Known as HD3; RPD3; KDAC3; RPD3-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8841

About HDAC3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,620,881-141,636,849 (from NCBI)

This gene has 16 transcripts (splice variants), 155 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and Apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

HDAC3 Products (10)

mRNA	Protein	Name
NR_149169.2
NM_001355041.2	NP_001341970.1	histone deacetylase 3 isoform 4
NR_149167.2
NM_001355040.2	NP_001341969.1	histone deacetylase 3 isoform 3
NR_149166.2
NR_149164.2
NM_003883.4	NP_003874.2	histone deacetylase 3 isoform 2
NR_149168.2
NR_149165.2
NM_001355039.2	NP_001341968.1	histone deacetylase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17785205	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16569215	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	18417529	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables histone deacetylase activity	IMP IMP: Inferred from mutant phenotype	16924111	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables histone decrotonylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11006275	GOA
enables protein de-2-hydroxyisobutyrylase activity	IDA IDA: Inferred from direct assay	29192674	GOA
enables protein decrotonylase activity	IDA IDA: Inferred from direct assay	34608293	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	15653507	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16569215	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	12628926	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	10898795	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	25301942	GOA
involved in cellular response to fluid shear stress	IDA IDA: Inferred from direct assay	25190803	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: Inferred from direct assay	34608293	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16924111	GOA
involved in negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11931768	GOA
NOT involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	10983972	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16569215	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12628926	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	25190803	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	25190803	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	25190803	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25190803	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	21030595	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	25190803	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	18326024	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25190803	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21030595	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	18326024	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	18326024	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18326024	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	11804585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC3 Protein Structure

Hist_deacetyl

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 3	SMAP45 protein deacetylase HDAC3 protein deacylase HDAC3

HDAC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HDAC3	O15379	AKAP8	Homo sapiens	O43823	Confocal	16980585
Intra	HDAC3	O15379	AKAP8	Homo sapiens	O43823	Anti Tag CoIP	16980585
Intra	HDAC3	O15379	AKAP8	Homo sapiens	O43823	Anti Bait CoIP	16980585
Intra	HDAC3	O15379	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	23079660
Intra	HDAC3	O15379	NCOR1	Homo sapiens	O75376	Anti Tag CoIP	23752268
Intra	HDAC3	O15379	NCOR1	Homo sapiens	O75376	Anti Tag CoIP	35271311
Intra	HDAC3	O15379	NCOR1	Homo sapiens	O75376	Affinity Chrom	11013263
Intra	HDAC3	O15379	NCOR1	Homo sapiens	O75376	Anti Tag CoIP	16980585
Intra	HDAC3	O15379	NCOR1	Homo sapiens	O75376	Anti Bait CoIP	21258344
Cross	HDAC3	O15379	Ncor1	Mus musculus	Q60974	Anti Tag CoIP	16917504
Cross	HDAC3	O15379	Ncor1	Mus musculus	Q60974	Anti Tag CoIP	17956988
Intra	HDAC3	O15379	AKAP8L	Homo sapiens	Q9ULX6	Anti Tag CoIP	16980585
Intra	HDAC3	O15379	AKAP8L	Homo sapiens	Q9ULX6	Anti Bait CoIP	16980585
Intra	HDAC3	O15379	MYC	Homo sapiens	P01106	Anti Bait CoIP	23079660
Intra	HDAC3	O15379	MYC	Homo sapiens	P01106	CH-IP	23079660
Intra	HDAC3	O15379	MAGEA2	Homo sapiens	P43356	Anti Tag CoIP	16847267
Intra	HDAC3	O15379	PGK1	Homo sapiens	P00558	Anti Bait CoIP	26356530
Intra	HDAC3	O15379	PGK1	Homo sapiens	P00558	Anti Tag CoIP	26356530
Intra	HDAC3	O15379	KDM1A	Homo sapiens	O60341	Confocal	23752268
Intra	HDAC3	O15379	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23752268
Intra	HDAC3	O15379	KDM1A	Homo sapiens	O60341	Anti Bait CoIP	21258344
Intra	HDAC3	O15379	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	23752268
Intra	HDAC3	O15379	GPS2	Homo sapiens	Q13227	Anti Bait CoIP	21258344
Intra	HDAC3	O15379	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	35271311
Intra	HDAC3	O15379	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	16980585
Intra	HDAC3	O15379	L3MBTL2	Homo sapiens	Q969R5	IF	20385135
Intra	HDAC3	O15379	L3MBTL2	Homo sapiens	Q969R5	Pull Down	20385135
Intra	HDAC3	O15379	APPL1	Homo sapiens	Q9UKG1	Anti Bait CoIP	23752268
Intra	HDAC3	O15379	APPL1	Homo sapiens	Q9UKG1	Anti Tag CoIP	23752268
Intra	HDAC3	O15379	NRIP1	Homo sapiens	P48552	Y2H	17053781
Intra	HDAC3	O15379	NRIP1	Homo sapiens	P48552	Anti Bait CoIP	17053781
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	X-Ray Diffraction	22230954
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Tag CoIP	22230954
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Bait CoIP	21624135
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Bait CoIP	21258344
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Bait CoIP	16980585
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Deacetylase Assay	22230954
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	GMS	22230954
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Tag CoIP	23752268
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Tag CoIP	35271311
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Tag CoIP	16980585
Intra	HDAC3	O15379	NCOR2	Homo sapiens	Q9Y618	Anti Bait CoIP	16924111
Intra	HDAC3	O15379	MBD1	Homo sapiens	Q9UIS9	Anti Tag CoIP	16432238
Cross	HDAC3	O15379	ICP0	Human herpesvirus 1	P08393	CoIP	15194749
Cross	HDAC3	O15379	ICP0	Human herpesvirus 1	P08393	Pull Down	15194749

Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80152	HDAC3 Antibody (YA392)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
HY-P85198	HDAC3 Antibody (YA4890)	WB, ICC/IF, ELISA	Human, Mouse
HY-P85198A	HDAC3 Antibody (YA4890)(PBS only)	WB, ICC/IF, ELISA	Human, Mouse
HY-P85432	HDAC3 Antibody (YA5124)	WB	Human, Mouse, Rat, Dog, Pig, Rabbit
HY-P85562	HDAC3 Antibody (YA5254)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures	OPA10 Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures Optic Atrophy 10 Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10221	Vorinostat	Inhibitor	99.96%	Yes
HY-109015	Tucidinostat	Inhibitor	98.74%	Unkown
HY-12164	Mocetinostat	Inhibitor	99.68%	Yes
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-B0494	Bufexamac	Inhibitor	98.47%	Unkown
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes

Clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14718A	Resminostat hydrochloride	Inhibitor	99.67%	Phase 4
HY-12163	Entinostat	Inhibitor	99.98%	Phase 3
HY-50934	Tacedinaline	Inhibitor	99.32%	Phase 3
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3
HY-175513	ZWZH-21	Inhibitor	/	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-153358	TNG260	Inhibitor	99.33%	Phase 2
HY-100748	Zabadinostat	Inhibitor	99.83%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.34%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.64%	Phase 2
HY-14718	Resminostat	Inhibitor	99.44%	Phase 2
HY-13432	Nanatinostat	Inhibitor	99.67%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-13432A	Nanatinostat TFA	Inhibitor	/	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-16425	RG2833	Inhibitor	99.31%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.55%	Phase 1

Pre-clinical Phase

Bioactive Molecules (160)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13909	RGFP966	Inhibitor	99.81%	Unkown
HY-13428	Tubacin	Inhibitor	97.11%	Unkown
HY-125771	1-Stearoyl-sn-glycero-3-phosphocholine	Inhibitor	99.53%	Unkown
HY-19618	BRD3308	Inhibitor	98.34%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-100719	BRD-6929	Inhibitor	99.01%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-18613	CAY10603	Inhibitor	99.76%	Unkown
HY-111400	SR-4370	Inhibitor	98.38%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.78%	Unkown
HY-19328	ACY-775	Inhibitor	99.71%	Unkown
HY-104008	ACY-957	Inhibitor	99.63%	Unkown
HY-13267	Droxinostat	Inhibitor	99.08%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.10%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-164233	YX968	Inhibitor	98.06%	Unkown
HY-102083	BRD4884	Inhibitor	99.14%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.91%	Unkown
HY-18976	UF010		99.83%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.54%	Unkown
HY-149669	PH14	Inhibitor	99.29%	Unkown
HY-18712	BG45	Inhibitor	99.95%	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-W009776	Suberoyl bis-hydroxamic acid	Inhibitor	95.0%	Unkown
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-116818	Crebinostat	Inhibitor	98.83%	Unkown
HY-100871	WT-161	Inhibitor	98.04%	Unkown
HY-124053	BRD2492	Inhibitor	99.22%	Unkown
HY-146346	HD-TAC7	Degrader	98.53%	Unkown
HY-114483	AES-135	Inhibitor	98.68%	Unkown
HY-119017	SB-429201	Inhibitor	98.15%	Unkown
HY-19747	HPOB	Inhibitor	99.54%	Unkown
HY-100384	NKL 22	Inhibitor	97.26%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-18700	BRD73954	Inhibitor	99.13%	Unkown
HY-125771S	1-Stearoyl-sn-glycero-3-phosphocholine-d35	Inhibitor	99%	Unkown
HY-110280	MC1742	Inhibitor	98.95%	Unkown
HY-142690A	HDAC-IN-27 dihydrochloride	Inhibitor	99.08%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-152174	HDAC-IN-52	Inhibitor	99.46%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-138831	AES-350	Inhibitor	99.30%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.12%	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	98.63%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-168287	HDAC3/8 ligand-1		/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-117374	HDAC3-IN-1	Inhibitor	99.28%	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-154855	HDAC-IN-56	Inhibitor	/	Unkown
HY-181009	HDAC-IN-98	Inhibitor	98.36%	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-162487	HDAC-IN-72	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-N16881	Andrographidine E	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-172889	PI3K/HDAC-IN-4	Inhibitor	/	Unkown
HY-183150	HDAC1-IN-13	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-182720	FT108	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-147840	HDAC-IN-41	Inhibitor	/	Unkown
HY-179654	ST13	Inhibitor	/	Unkown
HY-162769	HDAC3-IN-5	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-172136	LSQ-28	Inhibitor	/	Unkown
HY-173330	HDAC-IN-89	Inhibitor	/	Unkown
HY-180214	HDAC6-IN-69	Inhibitor	/	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-172601	HDAC3-IN-7	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-178333	HDAC6-IN-66	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-181767	PROTAC HDAC3 degrader-1	Degrader	/	Unkown
HY-175671	LSD1/HDAC-IN-3	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-179682	HDAC3 degrader-1	Degrader	/	Unkown
HY-176904	JPS004	Degrader	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-179272	Wee1/HDAC-IN-1	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-181640	HDAC1/3-IN-1	Inhibitor	99.81%	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-179019	HDAC-IN-94	Inhibitor	/	Unkown
HY-150774	HDAC6/HSP90-IN-2	Inhibitor	/	Unkown
HY-162658	Leuxinostat	Inhibitor	/	Unkown
HY-184398	cGAS/HDAC-IN-1	Inhibitor	/	Unkown
HY-172133	HDAC3-IN-6	Inhibitor	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-145816	JPS016		/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-174398	GSK-3β/HDAC-IN-2	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-176733	HDAC6-IN-61	Inhibitor	/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-179271	CA/HDAC-IN-1	Inhibitor	/	Unkown
HY-161154	HDAC3-IN-3	Inhibitor	/	Unkown
HY-168962	HDAC-IN-88	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-184415	Syk/HDAC6-IN-1	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-172359	PROTAC HDAC6 degrader 4	Degrader	/	Unkown
HY-178110	HDAC6-IN-65	Inhibitor	/	Unkown
HY-153583	HDAC8-IN-4	Inhibitor	/	Unkown
HY-181579	HDAC6-IN-74	Inhibitor	/	Unkown
HY-176561	IOR-160	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-172891	CDK9/HDAC1/HDAC3-IN-1	Inhibitor	/	Unkown
HY-175805	EGFR/HDAC-IN-2	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-173064	DS-103	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown
HY-119316	CM-414	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-181768	HDAC3-IN-8	Inhibitor	/	Unkown
HY-P11678	HDAC-IN-100	Inhibitor	/	Unkown
HY-163894	HDAC6-IN-48	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-142690	HDAC-IN-27	Inhibitor	98.12%	Unkown
HY-153514	HDAC-IN-54	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-173520	EGFR/HDAC-IN-1	Inhibitor	/	Unkown
HY-172167	PD-L1/HDAC-IN-1	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HDAC3	VGNC	VGNC:67549
Canis familiaris	HDAC3	VGNC	VGNC:50628
Rattus norvegicus	HDAC3	RGD	RGD:619977
Mus musculus	HDAC3	MGD	MGI:1343091
Bos taurus	HDAC3	VGNC	VGNC:106764
Macaca mulatta	HDAC3	VGNC	VGNC:73359
Others	HDAC3	NCBI