1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Suberoyl bis-hydroxamic acid

Suberoyl bis-hydroxamic acid (Synonyms: Suberohydroxamic acid; SBHA)

Cat. No.: HY-W009776 Purity: >98.0%
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Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC).

For research use only. We do not sell to patients.

Suberoyl bis-hydroxamic acid Chemical Structure

Suberoyl bis-hydroxamic acid Chemical Structure

CAS No. : 38937-66-5

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10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
50 mg USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 95 In-stock
Estimated Time of Arrival: December 31
250 mg USD 265 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively[1].Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways[2].Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC)[3].

IC50 & Target[1]

HDAC1

0.25 μM (IC50)

HDAC3

0.30 μM (IC50)

In Vitro

Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death[1].
Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells[1].
Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells[2].

Apoptosis Analysis[1]

Cell Line: MM-BI and Ist-Mes2 cells
Concentration: 10 μM, 20 μM or 50 μM
Incubation Time: 24 hours
Result: Showed a cooperative effect in cell apoptosis.
In Vivo

Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth[3].

Animal Model: Nude mice injected with human MTC cells[3]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; every 2 days; 12 days
Result: Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.
Molecular Weight

204.22

Formula

C₈H₁₆N₂O₄

CAS No.

38937-66-5

SMILES

O=C(NO)CCCCCCC(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Suberoyl bis-hydroxamic acidSuberohydroxamic acidSBHAHDACHistone deacetylasesneoplastic diseaseMalignantmesotheliomaMMneoplasiaMedullarythyroidcarcinomaMTCneuroendocrine malignancyInhibitorinhibitorinhibit

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Suberoyl bis-hydroxamic acid
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