PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))
(Pink: HDAC6 ligand (HY-172360); Blue: Cereblon ligand (HY-W093272); Black: linker (HY-138387)).
For research use only. We do not sell to patients.
- Formula: C39H42FN9O7
- Molecular Weight:767.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HDAC6 14 nM (DC50) |
HDAC6 0.295 μM (IC50) |
HDAC3 0.611 μM (IC50) |
HDAC1 2.2 μM (IC50) |
HDAC2 2.37 μM (IC50) |
Chemical Information
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Molecular Weight 767.81
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Formula C39H42FN9O7
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SMILES
O=C(NCC1=CC=C(C(NNCC)=O)C=C1)C2=CC=C(OCC3=CN(CCCCCCNC4=CC5=C(C(N(C(CC6)C(NC6=O)=O)C5=O)=O)C=C4F)N=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HDAC6 degrader 4 Related Classifications
HY-172359 Related Classifications
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