Thalidomide-5,6-F
Based on 1 Customer Validation
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
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- Reinheit : 99.84%
- CAS. Nr.: 1496997-41-1
- Formel: C13H8F2N2O4
- Molecular Weight:294.21
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-41547
Thalidomide 4-fluorideLigands for E3 Ligase -
HY-103596
Thalidomide-4-OHCereblon Ligand -
HY-W087383
Thalidomide 5-fluorideLigand for E3 Ligase -
HY-W023573
5-AminothalidomideLigands for E3 Ligase -
HY-23095
Thalidomide-5-OHLigands for E3 Ligase -
HY-103596R
Thalidomide-4-OH (Standard)Reference Standard -
HY-100947
VH-298VHL:HIF-α Interaction Inhibitor -
HY-W069604
Thalidomide-5-BrThalidomide Analogue -
HY-23095R
Thalidomide-5-OH (Standard)Ligands for E3 Ligase -
HY-139539
Thalidomide-5-COOHLigand for E3 Ligase -
HY-125845
(S,R,S)-AHPCVHL Ligand -
HY-103597
Thalidomide-O-COOHCereblon Ligand
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1496997-41-1
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Appearance Solid
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Molecular Weight 294.21
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Formel C13H8F2N2O4
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Color Gray to dark gray
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(F)=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 33.33 mg/mL (113.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3989 mL | 16.9947 mL | 33.9893 mL | 84.9733 mL |
| 5 mM | 0.6798 mL | 3.3989 mL | 6.7979 mL | 16.9947 mL | |
| 10 mM | 0.3399 mL | 1.6995 mL | 3.3989 mL | 8.4973 mL | |
| 15 mM | 0.2266 mL | 1.1330 mL | 2.2660 mL | 5.6649 mL | |
| 20 mM | 0.1699 mL | 0.8497 mL | 1.6995 mL | 4.2487 mL | |
| 25 mM | 0.1360 mL | 0.6798 mL | 1.3596 mL | 3.3989 mL | |
| 30 mM | 0.1133 mL | 0.5665 mL | 1.1330 mL | 2.8324 mL | |
| 40 mM | 0.0850 mL | 0.4249 mL | 0.8497 mL | 2.1243 mL | |
| 50 mM | 0.0680 mL | 0.3399 mL | 0.6798 mL | 1.6995 mL | |
| 60 mM | 0.0566 mL | 0.2832 mL | 0.5665 mL | 1.4162 mL | |
| 80 mM | 0.0425 mL | 0.2124 mL | 0.4249 mL | 1.0622 mL | |
| 100 mM | 0.0340 mL | 0.1699 mL | 0.3399 mL | 0.8497 mL |
Thalidomide-5,6-F Related Classifications
HY-W093272 Related Classifications
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