Thalidomide-5,6-F
Based on 1 Customer Validation
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 1496997-41-1
- Formula: C13H8F2N2O4
- Molecular Weight:294.21
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Cancer Compound Library
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Autophagy Compound Library
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Ubiquitination Compound Library
HY-L050
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E3 Ligase Ligand Library
HY-L128
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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3D Diverse Fragment Library
HY-L903
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MCE Kinase Hinge Binder Fragment Library
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Molecular Glue-like Compound Library
HY-L918
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1496997-41-1
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Appearance Solid
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Molecular Weight 294.21
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Formula C13H8F2N2O4
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Color Gray to dark gray
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(F)=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33.33 mg/mL (113.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3989 mL | 16.9947 mL | 33.9893 mL | 84.9733 mL |
| 5 mM | 0.6798 mL | 3.3989 mL | 6.7979 mL | 16.9947 mL | |
| 10 mM | 0.3399 mL | 1.6995 mL | 3.3989 mL | 8.4973 mL | |
| 15 mM | 0.2266 mL | 1.1330 mL | 2.2660 mL | 5.6649 mL | |
| 20 mM | 0.1699 mL | 0.8497 mL | 1.6995 mL | 4.2487 mL | |
| 25 mM | 0.1360 mL | 0.6798 mL | 1.3596 mL | 3.3989 mL | |
| 30 mM | 0.1133 mL | 0.5665 mL | 1.1330 mL | 2.8324 mL | |
| 40 mM | 0.0850 mL | 0.4249 mL | 0.8497 mL | 2.1243 mL | |
| 50 mM | 0.0680 mL | 0.3399 mL | 0.6798 mL | 1.6995 mL | |
| 60 mM | 0.0566 mL | 0.2832 mL | 0.5665 mL | 1.4162 mL | |
| 80 mM | 0.0425 mL | 0.2124 mL | 0.4249 mL | 1.0622 mL | |
| 100 mM | 0.0340 mL | 0.1699 mL | 0.3399 mL | 0.8497 mL |
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