1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. Pimelic Diphenylamide 106

Pimelic Diphenylamide 106  (Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII)

Cat. No.: HY-19348 Purity: 98.39%
COA Handling Instructions

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.

For research use only. We do not sell to patients.

Pimelic Diphenylamide 106 Chemical Structure

Pimelic Diphenylamide 106 Chemical Structure

CAS No. : 937039-45-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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10 mg USD 85 In-stock
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Based on 3 publication(s) in Google Scholar

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Description

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2) Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

IC50 & Target[1]

HDAC1

150 nM (IC50)

HDAC3

370 nM (IC50)

HDAC2

760 nM (IC50)

HDAC8

5000 nM (IC50)

Molecular Weight

339.43

Formula

C20H25N3O2

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (368.26 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9461 mL 14.7306 mL 29.4612 mL
5 mM 0.5892 mL 2.9461 mL 5.8922 mL
10 mM 0.2946 mL 1.4731 mL 2.9461 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.39%

References
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Pimelic Diphenylamide 106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pimelic Diphenylamide 106
Cat. No.:
HY-19348
Quantity:
MCE Japan Authorized Agent: