1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Pimelic Diphenylamide 106

Pimelic Diphenylamide 106 (Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII)

Cat. No.: HY-19348 Purity: >98.0%
Handling Instructions

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.

For research use only. We do not sell to patients.

Pimelic Diphenylamide 106 Chemical Structure

Pimelic Diphenylamide 106 Chemical Structure

CAS No. : 937039-45-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
25 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 240 In-stock
Estimated Time of Arrival: December 31
100 mg USD 440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2) Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

IC50 & Target[1]

HDAC1

150 nM (IC50)

HDAC3

370 nM (IC50)

HDAC2

760 nM (IC50)

HDAC8

5000 nM (IC50)

Molecular Weight

339.43

Formula

C₂₀H₂₅N₃O₂

CAS No.

937039-45-7

SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (73.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9461 mL 14.7306 mL 29.4612 mL
5 mM 0.5892 mL 2.9461 mL 5.8922 mL
10 mM 0.2946 mL 1.4731 mL 2.9461 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Pimelic Diphenylamide 106
Cat. No.:
HY-19348
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