1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Pyroxamide

Pyroxamide 

Cat. No.: HY-13216
Handling Instructions

Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.

For research use only. We do not sell to patients.

Pyroxamide Chemical Structure

Pyroxamide Chemical Structure

CAS No. : 382180-17-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 310 In-stock
Estimated Time of Arrival: December 31
100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.

IC50 & Target

ID50: 100 nM[1]

In Vitro

Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1].
Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1].

Cell Viability Assay[2]

Cell Line: RD cells; RH30B cells
Concentration: 1.25-20.0 μM
Incubation Time: 24 hours; 48 hours; 72 hours
Result: Resulted in a cell growth decrease in RD and RH30B cells.

Cell Cycle Analysis[2]

Cell Line: RD cells; RH30B cells
Concentration: 10.0 μM; 20.0 μM
Incubation Time: 48 hours
Result: Increased the sub-G1 fractions at 48 hours compared with control samples.
Molecular Weight

265.31

Formula

C₁₃H₁₉N₃O₃

CAS No.

382180-17-8

SMILES

O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (471.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7692 mL 18.8459 mL 37.6918 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL
10 mM 0.3769 mL 1.8846 mL 3.7692 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
Pyroxamide
Cat. No.:
HY-13216
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