1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. SIS17

SIS17 

Cat. No.: HY-128918 Purity: 98.82%
Handling Instructions

SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

For research use only. We do not sell to patients.

SIS17 Chemical Structure

SIS17 Chemical Structure

CAS No. : 2374313-54-7

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 690 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs[1].

IC50 & Target

IC50: 0.83 μM (HDAC 11)[1]

Molecular Weight

366.60

Formula

C₂₁H₃₈N₂OS

CAS No.

2374313-54-7

SMILES

O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (340.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7278 mL 13.6388 mL 27.2777 mL
5 mM 0.5456 mL 2.7278 mL 5.4555 mL
10 mM 0.2728 mL 1.3639 mL 2.7278 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
SIS17
Cat. No.:
HY-128918
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