Cat. No.: HY-128918

SIS17

9 Cited Publications

Customer Review

Based on 9 publication(s) in Google Scholar

SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs.

For research use only. We do not sell to patients.

Purity: 99.43%
CAS No.: 2374313-54-7
Formula: C₂₁H₃₈N₂OS
Molecular Weight:366.60

Storage:

Powder -20°C, 3 years , 4°C, 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

SIS17 Chemical Structure

CAS No.: 2374313-54-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (9)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC11

0.83 μM (IC₅₀)

All HDAC Isoforms :

In Vitro

SIS17 (0-50 μM, 6 h) increases the fatty acylation level of SHMT2 in MCF7 cells^[1].
SIS17 (48 h) combined with Oxaliplatin (HY-17371) shows a synergistic cytotoxicity in K562 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2374313-54-7
Appearance Solid
Molecular Weight 366.60
Formula C₂₁H₃₈N₂OS
Color White to off-white
SMILES

O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (9)

All Flow CytometryIn Vivo Efficacy StudyCell Proliferation/Viability AssayRT-PCRWB

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Journal Impact Factor

Cancer Cell

Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer. [Abstract]

2024 Oct 14;42(10):1729-1746.e8. PMID: 39303724
Cell Metab

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis. [Abstract]

2021 Dec 7;33(12):2355-2366.e8. PMID: 34847376
Redox Biol

HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3. [Abstract]

2022 Oct:56:102461. PMID: 36087429

SIS17 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]

SIS17 (24 mg/kg; IP; daily for 4 days) increased the survival rate in WT C57BL/6 mice were intravenously injected with 2 ×105 CFU of C. albicans per mouse.
J Exp Clin Cancer Res

CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages. [Abstract]

2025 Feb 24;44(1):67. PMID: 39994810

SIS17 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Feb 24;44(1):67. [Abstract]

HCT116 cells were treated with the indicated HDAC subtype inhibitors (SIS17; 0.5 μM) for 24 h, the surface levels of CD47 were evaluated by flow cytometry.
Adv Sci (Weinh)

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion. [Abstract]

2025 Aug 7:e02624. PMID: 40772426

SIS17 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 7:e02624. [Abstract]

SIS17 (25 μM) showed no effect on the mRNA expression of FGF1B in NCM460 cells.

SIS17 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 7:e02624. [Abstract]

SIS17 (25 μM) showed no effect on the expression of acetylated H3 and FGF1 in NCM460 cells.
J Med Chem

Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. [Abstract]

2024 Sep 12;67(17):15098-15117. PMID: 39145486

SIS17 purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15098-15117. [Abstract]

Viability of PC-9 cells treated with different HDAC inhibitors and in combination with Fer-1 (1 μM) for 24 h (n = 3) (Vorinostat, Panobinostat, Romidepsin, and Entinostat at 2 μM; BRD2492, RGFP966, PCI34051, TMP195, Tubastatin A, DFKZ728, and SIS17 at 10 μM).
FASEB J

A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. [Abstract]

2022 Jul;36(7):e22326. PMID: 35657209
Comput Biol Med

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors. [Abstract]

2025 Jul 4;196(Pt A):110695. PMID: 40617084
Chemrxiv

2024 Jan 9.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7278 mL

13.6388 mL

27.2777 mL

5 mM

0.5456 mL

2.7278 mL

5.4555 mL

10 mM

0.2728 mL

1.3639 mL

2.7278 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (5.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2 mg/mL (5.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. [Content Brief]

[2]. Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7278 mL	13.6388 mL	27.2777 mL	68.1942 mL
	5 mM	0.5456 mL	2.7278 mL	5.4555 mL	13.6388 mL
	10 mM	0.2728 mL	1.3639 mL	2.7278 mL	6.8194 mL
	15 mM	0.1819 mL	0.9093 mL	1.8185 mL	4.5463 mL
	20 mM	0.1364 mL	0.6819 mL	1.3639 mL	3.4097 mL
	25 mM	0.1091 mL	0.5456 mL	1.0911 mL	2.7278 mL
	30 mM	0.0909 mL	0.4546 mL	0.9093 mL	2.2731 mL
	40 mM	0.0682 mL	0.3410 mL	0.6819 mL	1.7049 mL
	50 mM	0.0546 mL	0.2728 mL	0.5456 mL	1.3639 mL
	60 mM	0.0455 mL	0.2273 mL	0.4546 mL	1.1366 mL
	80 mM	0.0341 mL	0.1705 mL	0.3410 mL	0.8524 mL
	100 mM	0.0273 mL	0.1364 mL	0.2728 mL	0.6819 mL

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SIS17

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) SIS17

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (9)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SIS17

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) SIS17

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (9)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SIS17 Related Classifications

HY-128918 Related Classifications