1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

ITSA-1 

Cat. No.: HY-100508 Purity: >98.0%
Handling Instructions

ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors.

For research use only. We do not sell to patients.
ITSA-1 Chemical Structure

ITSA-1 Chemical Structure

CAS No. : 200626-61-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
25 mg USD 84 In-stock
50 mg USD 144 In-stock
100 mg USD 240 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target:TSA. In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

IC50 & Target[1]

HDAC

 

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4233 mL 17.1163 mL 34.2325 mL
5 mM 0.6847 mL 3.4233 mL 6.8465 mL
10 mM 0.3423 mL 1.7116 mL 3.4233 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

292.12

Formula

C₁₃H₇Cl₂N₃O

CAS No.

200626-61-5

SMILES

O=C(N1N=NC2=CC=CC=C21)C3=CC=C(Cl)C=C3Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
ITSA-1
Cat. No.:
HY-100508
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