1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

ITSA-1 

Cat. No.: HY-100508 Purity: >98.0%
Handling Instructions

ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors.

For research use only. We do not sell to patients.

ITSA-1 Chemical Structure

ITSA-1 Chemical Structure

CAS No. : 200626-61-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Top Publications Citing Use of Products

    ITSA-1 purchased from MCE. Usage Cited in: BMC Cancer. 2019 Mar 22;19(1):262.

    Western blot is used to examine the protein levels of cell proliferation (PCNA), cell cycle (cyclinD1, CDK2 and p16) and EMT-associated genes (E-cadherin and Vimentin) in the treatment of TSA or TSA plus ITSA-1.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target:TSA. In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

    IC50 & Target[1]

    HDAC

     

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (109.54 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4233 mL 17.1163 mL 34.2325 mL
    5 mM 0.6847 mL 3.4233 mL 6.8465 mL
    10 mM 0.3423 mL 1.7116 mL 3.4233 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    292.12

    Formula

    C₁₃H₇Cl₂N₃O

    CAS No.

    200626-61-5

    SMILES

    O=C(N1N=NC2=CC=CC=C21)C3=CC=C(Cl)C=C3Cl

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

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    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    ITSA-1
    Cat. No.:
    HY-100508
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    ITSA-1

    Cat. No.: HY-100508