2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. CRA-026440 hydrochloride

CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities. CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CRA-026440 hydrochloride Chemical Structure

CRA-026440 hydrochloride Chemical Structure

CAS No. : 847459-98-7

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Based on 1 publication(s) in Google Scholar

Other Forms of CRA-026440 hydrochloride:

CRA-026440 hydrochloride Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities[1]. CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

HDAC1

4 nM (IC50)

HDAC2

14 nM (IC50)

HDAC3/SMRT

11 nM (IC50)

HDAC6

15 nM (IC50)

HDAC8

7 nM (IC50)

HDAC10

20 nM (IC50)

In Vitro

CRA-026440 hydrochloride has antiproliferative effect on HUVEC endothelial cells with a GI50 value of 1.41 μM[1].
CRA-026440 hydrochloride (0.1-10 μM; 18 hours) results in the accumulation of acetylated histone and acetylated tubulin, leading to an inhibition of tumor cell growth and the induction of apoptosis[1].
CRA-026440 hydrochloride (0.1-10 μM; 5 days) inhibits ex vivo angiogenesis in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRA-026440 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM
Incubation Time: 18 hours
Result: Resulted in the accumulation of both acetylated histones and acetylated tubulin. Induced expression of the cyclin-dependent kinase inhibitor p21Cip1/WAF1.
In Vivo

CRA-026440 hydrochloride (100 mg/kg; i.v.; daily; for three consecutive days) results in a statistically significant reduction in tumor growth in mice harboring HCT116 or U937 human tumor xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 tumor-bearing nude mice[1]
Dosage: 100 mg/kg
Administration: i.v.; daily; for three consecutive days
Result: Resulted in a statistically significant reduction in tumor growth.
Molecular Weight

456.92

Formula

C23H25ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N1)=CC2=C1C=CC(OCCN(C)C)=C2)NCC#CC3=CC=C(C(NO)=O)C=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1886 mL 10.9428 mL 21.8857 mL
5 mM 0.4377 mL 2.1886 mL 4.3771 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1886 mL 10.9428 mL 21.8857 mL 54.7142 mL
5 mM 0.4377 mL 2.1886 mL 4.3771 mL 10.9428 mL
10 mM 0.2189 mL 1.0943 mL 2.1886 mL 5.4714 mL
15 mM 0.1459 mL 0.7295 mL 1.4590 mL 3.6476 mL
20 mM 0.1094 mL 0.5471 mL 1.0943 mL 2.7357 mL
25 mM 0.0875 mL 0.4377 mL 0.8754 mL 2.1886 mL
30 mM 0.0730 mL 0.3648 mL 0.7295 mL 1.8238 mL
40 mM 0.0547 mL 0.2736 mL 0.5471 mL 1.3679 mL
50 mM 0.0438 mL 0.2189 mL 0.4377 mL 1.0943 mL
60 mM 0.0365 mL 0.1824 mL 0.3648 mL 0.9119 mL
80 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6839 mL
100 mM 0.0219 mL 0.1094 mL 0.2189 mL 0.5471 mL
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CRA-026440 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRA-026440847459-98-7CRA026440CRA 026440HDACApoptosisHistone deacetylasesHDAC1HDAC2HDAC3HDAC8HDAC6HDAC10antitumor and antiangiogenic activitiesInhibitorinhibitorinhibit

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CRA-026440 hydrochloride
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