CRA-026440 hydrochloride
Based on 1 publication(s) in Google Scholar
CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities. CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Purity: 98.12%
- CAS No.: 847459-98-7
- 화학식: C23H25ClN4O4
- 분자량:456.92
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CRA-026440 hydrochloride
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Biological Activity
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HDAC1 4 nM (IC50) |
HDAC2 14 nM (IC50) |
HDAC3/SMRT 11 nM (IC50) |
HDAC6 15 nM (IC50) |
HDAC8 7 nM (IC50) |
HDAC10 20 nM (IC50) |
CRA-026440 hydrochloride has antiproliferative effect on HUVEC endothelial cells with a GI50 value of 1.41 μM[1].
CRA-026440 hydrochloride (0.1-10 μM; 18 hours) results in the accumulation of acetylated histone and acetylated tubulin, leading to an inhibition of tumor cell growth and the induction of apoptosis[1].
CRA-026440 hydrochloride (0.1-10 μM; 5 days) inhibits ex vivo angiogenesis in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM
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Incubation Time:18 hours
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Result:Resulted in the accumulation of both acetylated histones and acetylated tubulin. Induced expression of the cyclin-dependent kinase inhibitor p21Cip1/WAF1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCT-116 tumor-bearing nude mice[1]
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Dosage:100 mg/kg
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Administration:i.v.; daily; for three consecutive days
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Result:Resulted in a statistically significant reduction in tumor growth.
Chemical Information
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CAS No. 847459-98-7
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Appearance Solid
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분자량 456.92
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화학식 C23H25ClN4O4
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Color White to off-white
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SMILES
O=C(C(N1)=CC2=C1C=CC(OCCN(C)C)=C2)NCC#CC3=CC=C(C(NO)=O)C=C3.[H]Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 100 mg/mL (218.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1886 mL | 10.9428 mL | 21.8857 mL | 54.7142 mL |
| 5 mM | 0.4377 mL | 2.1886 mL | 4.3771 mL | 10.9428 mL | |
| 10 mM | 0.2189 mL | 1.0943 mL | 2.1886 mL | 5.4714 mL | |
| 15 mM | 0.1459 mL | 0.7295 mL | 1.4590 mL | 3.6476 mL | |
| 20 mM | 0.1094 mL | 0.5471 mL | 1.0943 mL | 2.7357 mL | |
| 25 mM | 0.0875 mL | 0.4377 mL | 0.8754 mL | 2.1886 mL | |
| 30 mM | 0.0730 mL | 0.3648 mL | 0.7295 mL | 1.8238 mL | |
| 40 mM | 0.0547 mL | 0.2736 mL | 0.5471 mL | 1.3679 mL | |
| 50 mM | 0.0438 mL | 0.2189 mL | 0.4377 mL | 1.0943 mL | |
| 60 mM | 0.0365 mL | 0.1824 mL | 0.3648 mL | 0.9119 mL | |
| 80 mM | 0.0274 mL | 0.1368 mL | 0.2736 mL | 0.6839 mL | |
| 100 mM | 0.0219 mL | 0.1094 mL | 0.2189 mL | 0.5471 mL |
CRA-026440 hydrochloride Related Classifications
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