LSD1/HDAC-IN-2
Based on 1 publication(s) in Google Scholar
LSD1/HDAC-IN-2 (Compound 20c) is the inhibitor for LSD and HDAC, that inhibits LSD1, HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50s of 39.0, 1.4, 1.0, 1.3, 2.9 and 16.0 nM, respectively. LSD1/HDAC-IN-2 inhibits the proliferation of cancer cells, especially the colorectal cancer cells. LSD1/HDAC-IN-2 arrests the cell cycle at G2/M phase, inhibits cell migration, and induces apoptosis in HCT-116 and HT-29 cells. LSD1/HDAC-IN-2 exhibits antitumor efficacy in mouse model without significant toxicity.
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- CAS No.: 2966782-82-9
- Formule: C23H26N4O2
- Masse moléculaire:390.48
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Publications Citing Use of MedChemExpress (MCE) LSD1/HDAC-IN-2
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Activité biologique
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HDAC2 1.0 nM (IC50) |
HDAC3 1.3 nM (IC50) |
HDAC1 1.4 nM (IC50) |
HDAC6 2.9 nM (IC50) |
HDAC8 16.0 nM (IC50) |
KDM1/LSD1 39.0 nM (IC50) |
Chemical Information
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CAS No. 2966782-82-9
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Masse moléculaire 390.48
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Formule C23H26N4O2
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SMILES
NC1=C(C)C(C2=CN(CCCCCCC(NO)=O)C3=C2C=C(C#N)C=C3)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1/HDAC-IN-2 Related Classifications
HY-169938 Related Classifications
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