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Malate dehydrogenase (EC 1.1.1.37) (MDH) catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes [1].
Alcohol dehydrogenase is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol [1].
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H2O. Glutathione Peroxidase is an effective antioxidant against oxidative stress [1].
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC50s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively [1].
SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
SRT 1460, a potent Sirtuin-1(SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues [1].
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.
SRT 2183 is a selective Sirtuin-1(SIRT1) activator with an EC1.5 value of 0.36 μM [1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .
Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues [1].
Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer [1] .
Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer [1] .
Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer [1] .
Alcohol dehydrogenase is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol [1].
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H2O. Glutathione Peroxidase is an effective antioxidant against oxidative stress [1].
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC50s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively [1].
GLXR is a multifunctional enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase activities. It promotes the conversion of hydroxypyruvic acid into D-glyceric acid, glyoxylic acid into glycolic acid, and oxidation of D-glyceric acid into hydroxypyruvic acid. GLXR Protein, Mouse (His-SUMO) is the recombinant mouse-derived GLXR protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of GLXR Protein, Mouse (His-SUMO) is 328 a.a., with molecular weight of ~51.3 kDa.
GhrA is an enzyme involved in cellular metabolism and plays a crucial role in catalyzing the NADPH-dependent reduction of glyoxylate to glycolate and hydroxypyruvate to glycerate. This enzymatic activity contributes to the conversion of important metabolites and contributes to metabolic pathways related to glyoxylate detoxification and maintenance of cellular homeostasis. GhrA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived GhrA protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GhrA Protein, E.coli (His-SUMO) is 312 a.a., with molecular weight of ~51.4 kDa.
FXN protein activates persulfide transfer in the ISC assembly complex, promoting sulfur transfer and leading to persulfide and sulfide release. It binds ferrous ions, initiates [2Fe-2S] cluster synthesis, and transfers it to chaperone proteins. FXN Protein, Rat is the recombinant rat-derived FXN protein, expressed by E. coli , with tag free. The total length of FXN Protein, Rat is 168 a.a., with molecular weight of ~18.6 kDa.
FXN protein is a key activator in the core iron-sulfur cluster (ISC) assembly complex, accelerating persulfide transfer to ISCU and [2Fe-2S] cluster assembly. It promotes sulfur transfer, leading to oversulfidation and sulfide release. FXN Protein, Mouse (His) is the recombinant mouse-derived FXN protein, expressed by E. coli , with N-6*His labeled tag. The total length of FXN Protein, Mouse (His) is 130 a.a., with molecular weight of ~19.9 kDa.
The Rnls protein catalyzes the oxidation of the less abundant 1,2-dihydro-β-NAD(P) and 1,6-dihydro-β-NAD(P) to form β-NAD(P)(+). Mainly secreted by the kidneys, this enzyme circulates in the blood and plays a vital role in regulating heart function and systemic blood pressure. Rnls Protein, Mouse (His-SUMO) is the recombinant mouse-derived Rnls protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Rnls Protein, Mouse (His-SUMO) is 325 a.a., with molecular weight of ~52.0 kDa.
The GFER protein is a FAD-dependent sulfhydryl oxidase that restores redox-active disulfide bonds in CHCHD4/MIA40, an important partner for protein folding in the mitochondrial intermembrane space. GFER Protein, Rat (His-SUMO) is the recombinant rat-derived GFER protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GFER Protein, Rat (His-SUMO) is 198 a.a., with molecular weight of ~38.8 kDa.
Frataxin (FXN) protein activates persulfide transfer, which is critical for [2Fe-2S] cluster assembly. It accelerates sulfur transfer from NFS1 persulfide to ISCU and small thiols, resulting in oversulfide and sulfide release. Frataxin/FXN Protein, Cynomolgus (His) is the recombinant cynomolgus-derived Frataxin/FXN protein, expressed by E. coli , with N-6*His labeled tag. The total length of Frataxin/FXN Protein, Cynomolgus (His) is 130 a.a., with molecular weight (affected by relative charge) of ~22 KDa.
Hydroxy acid oxidase 1 (HAO1) is a multifunctional (S)-2-hydroxyacid oxidase with a strong preference for glycolate oxidation. This enzymatic process produces glyoxylic acid, an important precursor for the synthesis of glycine by alanine glyoxylate aminotransferase, which prevents glyoxylic acid accumulation and kidney stone formation. Hydroxyacid oxidase 1 Protein, Mouse (His) is the recombinant mouse-derived Hydroxyacid oxidase 1 protein, expressed by E. coli , with N-His labeled tag. The total length of Hydroxyacid oxidase 1 Protein, Mouse (His) is 370 a.a., with molecular weight of ~45.0 kDa.
ASPH protein phosphorylates SPRTN, facilitating its chromatin recruitment and decreasing replication stress. ASPH activates the G2/M checkpoint by phosphorylating and inhibiting PABIR1/FAM122A, leading to serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity. ASPH Protein, Human (His-SUMO) is the recombinant human-derived ASPH protein, expressed by E. coli, with N-6*His, N-SUMO labeled tag. The total length of ASPH Protein, Human (His-SUMO) is 196 a.a., with molecular weight of ~38.2 kDa.
The OGDC-E Protein, a vital component of the 2-oxoglutarate dehydrogenase complex, drives the conversion of 2-oxoglutarate to succinyl-CoA in the mitochondrion, a pivotal step in the Krebs cycle. It employs thiamine diphosphate for decarboxylation, connecting to the E2 enzyme and participating in nuclear histone succinylation with KAT2A. OGDC-E Protein, Mouse (His-SUMO) is the recombinant mouse-derived OGDC-E protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of OGDC-E Protein, Mouse (His-SUMO) is 329 a.a., with molecular weight of ~54 kDa.
LOXL4 Protein potentially modulates collagenous extracellular matrix formation, suggesting a role in regulating assembly or stability of collagen fibers. Its involvement indicates a contribution to the structural integrity of tissues. The specific mechanisms and contexts of LOXL4 in collagen matrix modulation are areas of interest, emphasizing its potential significance in tissue development and maintenance. Lysyl oxidase homolog 4 Protein, Mouse (His) is the recombinant mouse-derived Lysyl oxidase homolog 4 protein, expressed by E. coli , with N-His labeled tag. The total length of Lysyl oxidase homolog 4 Protein, Mouse (His) is 732 a.a., with molecular weight of ~85.9 kDa.
EGLP/GPX5 may constitute a protective system similar to glutathione peroxidase, protecting sperm membrane lipids from peroxidative damage. Despite the limited enzyme activity, the protective effect suggests an effect beyond enzyme function. EGLP/GPX5 Protein, Pig (His-Myc) is the recombinant pig-derived EGLP/GPX5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of EGLP/GPX5 Protein, Pig (His-Myc) is 198 a.a., with molecular weight of ~27.6 kDa.
Hadh; Hadhsc; Mschad; Schad; Hydroxyacyl-coenzyme A dehydrogenase; mitochondrial; HCDH; EC 1.1.1.35; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase
HCDH Protein, pivotal in mitochondrial fatty acid beta-oxidation, manages the third step for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Beyond lipid metabolism, HCDH regulates insulin secretion by inhibiting glutamate dehydrogenase 1 (GLUD1) activation, a key enzyme in amino acid-induced insulin secretion. HCDH emerges as a pivotal factor in regulating cellular processes related to energy metabolism and glucose homeostasis. HCDH Protein, Mouse (His-SUMO) is the recombinant mouse-derived HCDH protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of HCDH Protein, Mouse (His-SUMO) is 302 a.a., with molecular weight of ~49.0 kDa.
Dxr/DXP Reductoisomerase is pivotal in isoprenoid biosynthesis, catalyzing the rearrangement and reduction of DXP to yield MEP. This step is critical in forming isoprenoid precursors, essential for cellular processes and metabolite synthesis. The enzyme's activity emphasizes its significance in regulating isoprenoid biosynthesis and cellular functions. Dxr/DXP reductoisomerase Protein, E.coli (Myc, His) is the recombinant E. coli-derived Dxr/DXP reductoisomerase protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of Dxr/DXP reductoisomerase Protein, E.coli (Myc, His) is 398 a.a., with molecular weight of ~48.4 kDa.
The azoreductase/NQO1 protein reduces quinones to hydroquinone using NADH or NADPH as an electron donor. Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Azoreductase/NQO1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is 273 a.a., with molecular weight of ~33 kDa.
CYP51 Proteinas is a sterol 14α-demethylase that acts with an unknown physiological substrate and accepts electrons from the iron-sulfur ferredoxin Fdx. In vitro, it catalyzes the C14-demethylation of lanosterol, 24,25-dihydrolanosterol, and obtanyol, showing stereoselectivity in producing 8,14-diene. CYP51 Protein, Mycobacterium tuberculosis (Baculovirus, His-Myc) is the recombinant CYP51 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of CYP51 Protein, Mycobacterium tuberculosis (Baculovirus, His-Myc) is 451 a.a., with molecular weight of ~54.8 kDa.
ERG11 Proteinas is a sterol 14α-demethylase, a key enzyme in the ergosterol biosynthetic pathway, particularly in the late pathway that occurs in the endoplasmic reticulum membrane. ERG11 catalyzes the three-step removal of the 14α-methyl group from lanosterol, releasing it as a formate, resulting in the conversion of the sterol into a key intermediate in ergosterol biosynthesis. ERG11 Protein, Saccharomyces cerevisiae (GST) is the recombinant ERG11 protein, expressed by E. coli , with N-GST labeled tag. The total length of ERG11 Protein, Saccharomyces cerevisiae (GST) is 20 a.a., with molecular weight of ~29.1 kDa.
Human, Mouse(predicted: Rat, Dog, Horse, Rabbit, Guinea Pig)
MPO Antibody is an unconjugated, approximately 84 kDa, rabbit-derived, anti-MPO polyclonal antibody. MPO Antibody can be used for: ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, dog, horse, rabbit, guinea pig background without labeling.
Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
HSD3B1 Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-HSD3B1 polyclonal antibody. HSD3B1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in mouse, rat, and predicted: human, dog, cow, horse background without labeling.
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