2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RG7800 tetrahydrochloride

RG7800 tetrahydrochloride  (Synonyms: RO6885247 tetrahydrochloride)

Cat. No.: HY-101792A Purity: 99.61%
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RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

For research use only. We do not sell to patients.

RG7800 tetrahydrochloride Chemical Structure

RG7800 tetrahydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 80 In-stock
10 mg USD 110 In-stock
50 mg USD 280 In-stock
100 mg USD 450 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of RG7800 tetrahydrochloride:

RG7800 tetrahydrochloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

IC50 & Target

EC1.5x: 23 nM (SMN2 splicing), 87 nM (SMN protein)[1]
In Vitro

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RG7800 tetrahydrochloride Related Antibodies
In Vivo

RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

562.36

Formula

C24H32Cl4N6O
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=CC(C2CCN(C)CC2)=CN3C1=NC(C4=NN(C=C(C)N=C5CC)C5=C4)=CC3=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 113.5 mg/mL (201.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7782 mL 8.8911 mL 17.7822 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Animal Administration
[1]

Mice[1]
Homozygous Δ7 mice are dosed ip with RG7800 or vehicle (100% DMSO, 2.5 mL/kg) once per day from PND3 through postnatal day 3 (PND23), and the dosing regimen is switched on PND24 to a 3-fold higher oral dose once daily in 0.5% HPMC and 0.1% Tween 80. Litters are randomized across groups. Body weight and survival are assessed daily. Survival analysis is done using GraphPad Prism (log-rank test), and a p <0.05 is considered as significant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7782 mL 8.8911 mL 17.7822 mL 44.4555 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL 8.8911 mL
10 mM 0.1778 mL 0.8891 mL 1.7782 mL 4.4456 mL
15 mM 0.1185 mL 0.5927 mL 1.1855 mL 2.9637 mL
20 mM 0.0889 mL 0.4446 mL 0.8891 mL 2.2228 mL
25 mM 0.0711 mL 0.3556 mL 0.7113 mL 1.7782 mL
30 mM 0.0593 mL 0.2964 mL 0.5927 mL 1.4819 mL
40 mM 0.0445 mL 0.2223 mL 0.4446 mL 1.1114 mL
50 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8891 mL
60 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7409 mL
80 mM 0.0222 mL 0.1111 mL 0.2223 mL 0.5557 mL
100 mM 0.0178 mL 0.0889 mL 0.1778 mL 0.4446 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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RG7800 tetrahydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG7800 tetrahydrochlorideRO6885247 tetrahydrochlorideDNA/RNA SynthesisInhibitorinhibitorinhibit

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