1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SRT 2183

SRT 2183 

Cat. No.: HY-19759
Handling Instructions

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

For research use only. We do not sell to patients.

SRT 2183 Chemical Structure

SRT 2183 Chemical Structure

CAS No. : 1001908-89-9

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Description

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2].

IC50 & Target[1]

SIRT1

0.36 μM (EC1.5)

In Vitro

SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner[2].
SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels[2].
SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival[3].

Cell Proliferation Assay[2]

Cell Line: Reh cells, Nalm-6 cells (pre-B acute lymphoblastic leukemia (ALL) cell lines)
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner. The IC50 (median inhibition concentration) values for SRT 2183-mediated inhibition of proliferation at 48 h are approximately 8.7 μM for Reh cells and approximately 3.2 μM for Nalm-6 cells.

Western Blot Analysis[2]

Cell Line: Reh cells, Ly3 cells
Concentration: 5μM and 10μM (Reh cells); 10μM (Ly3 cells)
Incubation Time: 24 hours
Result: Induced accumulation of phospho-H2A.X in Reh as well as in Ly3 cells.
References
Molecular Weight

468.57

Formula

C₂₇H₂₄N₄O₂S

CAS No.

1001908-89-9

SMILES

O=C(NC1=C(C2=CN3C(SC=C3CN4CC[[email protected]@H](O)C4)=N2)C=CC=C1)C(C=C5)=CC6=C5C=CC=C6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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SRT 2183
Cat. No.:
HY-19759
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SRT 2183

Cat. No.: HY-19759