HCDH Protein, Mouse (His-SUMO)
HCDH Protein, pivotal in mitochondrial fatty acid beta-oxidation, manages the third step for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Beyond lipid metabolism, HCDH regulates insulin secretion by inhibiting glutamate dehydrogenase 1 (GLUD1) activation, a key enzyme in amino acid-induced insulin secretion. HCDH emerges as a pivotal factor in regulating cellular processes related to energy metabolism and glucose homeostasis. HCDH Protein, Mouse (His-SUMO) is the recombinant mouse-derived HCDH protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
HCDH Protein, pivotal in mitochondrial fatty acid beta-oxidation, manages the third step for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Beyond lipid metabolism, HCDH regulates insulin secretion by inhibiting glutamate dehydrogenase 1 (GLUD1) activation, a key enzyme in amino acid-induced insulin secretion. HCDH emerges as a pivotal factor in regulating cellular processes related to energy metabolism and glucose homeostasis. HCDH Protein, Mouse (His-SUMO) is the recombinant mouse-derived HCDH protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
HCDH protein, a key participant in mitochondrial fatty acid beta-oxidation, orchestrates the third step of the beta-oxidation cycle specifically for medium and short-chain 3-hydroxy fatty acyl-CoAs ranging from C4 to C10. Beyond its role in lipid metabolism, HCDH exerts regulatory control over insulin secretion by impeding the activation of glutamate dehydrogenase 1 (GLUD1). This inhibition of GLUD1, a crucial enzyme in amino acid-induced insulin secretion, positions HCDH as a pivotal factor in the intricate regulation of cellular processes associated with energy metabolism and glucose homeostasis.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-His;N-SUMO
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Accession
Q61425-1 (S13-K314)
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Molecular Construction
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N-term
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6*His-SUMO
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HCDH (S13-K314)
Accession # Q61425-1 -
C-term
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Protein Length
Full Length of Isoform-1 Mature Protein
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Synonyms
HADH; HCDH; Prev. HADHSC; Testis Secretory Sperm-Binding Protein Li 203a; SCHAD; Hydroxyacyl-Coenzyme A Dehydrogenase; Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase; 3-Hydroxyacyl-CoA Dehydrogenase; Hydroxyacyl-Coenzyme A Dehydrogenase,
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AA Sequence
SSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
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Predicted Molecular Mass
49 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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