Rnls Protein, Mouse (His-SUMO)
The Rnls protein catalyzes the oxidation of the less abundant 1,2-dihydro-β-NAD(P) and 1,6-dihydro-β-NAD(P) to form β-NAD(P)(+). Mainly secreted by the kidneys, this enzyme circulates in the blood and plays a vital role in regulating heart function and systemic blood pressure. Rnls Protein, Mouse (His-SUMO) is the recombinant mouse-derived Rnls protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The Rnls protein catalyzes the oxidation of the less abundant 1,2-dihydro-β-NAD(P) and 1,6-dihydro-β-NAD(P) to form β-NAD(P)(+). Mainly secreted by the kidneys, this enzyme circulates in the blood and plays a vital role in regulating heart function and systemic blood pressure. Rnls Protein, Mouse (His-SUMO) is the recombinant mouse-derived Rnls protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
Renalase (Rnls) is an enzyme that catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). This enzyme is primarily secreted by the kidney, circulating in the blood and playing a crucial role in modulating cardiac function and systemic blood pressure. Renalase has been identified as a key factor in lowering blood pressure in vivo, achieved by decreasing cardiac contractility and heart rate while preventing a compensatory increase in peripheral vascular tone. This suggests a causal link between renalase, increased plasma catecholamine levels, and heightened cardiovascular risk. Notably, high concentrations of catecholamines activate plasma renalase, promoting its secretion and synthesis. The multifaceted functions of renalase underscore its significance in cardiovascular regulation and its potential as a therapeutic target for managing blood pressure and cardiovascular health.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-His;N-SUMO
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Accession
A7RDN6-1 (A18-I342)
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Molecular Construction
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N-term
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6*His-SUMO
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Rnls (A18-I342)
Accession # A7RDN6-1 -
C-term
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Protein Length
Full Length of Isoform-1 Mature Protein
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Synonyms
RNLS; FLJ11218; Prev. C10orf59; Chromosome 10 Open Reading Frame 59; Renalase; Alpha-NAD(P)H Oxidase/Anomerase; Monoamine Oxidase-C; Renalase, FAD Dependent Amine Oxidase; MAO-C
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AA Sequence
ALLRKEITAPLYLGLWDKGGDIGGRMITASSPHNPRCTADLGAQYITCSPHYVKEHQNFYEELLAHGILKPLTSPIEGMKGKEGDCNFVAPQGFSSVIKYYLKKSGAEVSLKHCVTQIHLKDNKWEVSTDTGSAEQFDLVILTMPAPQILELQGDIVNLISERQREQLKSVSYSSRYALGLFYEVGMKIGVPWSCRYLSSHPCICFISIDNKKRNIESSECGPSVVIQTTVPFGVQHLEASEADVQKLMIQQLETILPGLPQPVATICHKWTYSQVTSSVSDRPGQMTLHLKPFLVCGGDGFTHSNFNGCISSALSVMKVLKRYI
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Predicted Molecular Mass
52 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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