1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SRT 1460

SRT 1460 

Cat. No.: HY-124037
Handling Instructions

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5 > 300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.

For research use only. We do not sell to patients.

SRT 1460 Chemical Structure

SRT 1460 Chemical Structure

CAS No. : 925432-73-1

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Description

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5 > 300 μM), and is more potent than Resveratrol and the closest sirtuin homologues[1].

IC50 & Target[1]

SIRT1

2.9 μM (EC1.5)

In Vitro

SRT 1460 (2-6 μM; 72 hours) inhibits cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells are: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM[2].
SRT 1460 (5 μM; 16 hours) increases expression of the autophagy marker LC3-II[2].

Cell Viability Assay[2]

Cell Line: Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells
Concentration: 2 μM, 4 μM, 6 μM
Incubation Time: 72 hours
Result: Inhibited cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells were: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM.

Western Blot Analysis[2]

Cell Line: Patu8988t cells
Concentration: 5 μM
Incubation Time: 16 hours
Result: SRT1460 increased expression of the autophagy marker LC3-II.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

507.60

Formula

C₂₆H₂₉N₅O₄S

CAS No.

925432-73-1

SMILES

O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=CC(OC)=C(OC)C(OC)=C5

Shipping

Room temperature in continental US; may vary elsewhere

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SRT 1460
Cat. No.:
HY-124037
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SRT 1460

Cat. No.: HY-124037