1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SRT 1460

SRT 1460 

Cat. No.: HY-124037 Purity: 98.92%
Handling Instructions

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.

For research use only. We do not sell to patients.

SRT 1460 Chemical Structure

SRT 1460 Chemical Structure

CAS No. : 925432-73-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 112 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 530 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues[1].

IC50 & Target[1]

SIRT1

2.9 μM (EC1.5)

In Vitro

SRT 1460 (2-6 μM; 72 hours) inhibits cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells are: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM[2].
SRT 1460 (5 μM; 16 hours) increases expression of the autophagy marker LC3-II[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells
Concentration: 2 μM, 4 μM, 6 μM
Incubation Time: 72 hours
Result: Inhibited cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells were: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM.

Western Blot Analysis[2]

Cell Line: Patu8988t cells
Concentration: 5 μM
Incubation Time: 16 hours
Result: SRT1460 increased expression of the autophagy marker LC3-II.
Molecular Weight

507.60

Formula

C₂₆H₂₉N₅O₄S

CAS No.
SMILES

O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=CC(OC)=C(OC)C(OC)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (19.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9701 mL 9.8503 mL 19.7006 mL
5 mM 0.3940 mL 1.9701 mL 3.9401 mL
10 mM 0.1970 mL 0.9850 mL 1.9701 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.92%

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Keywords:

SRT 1460SRT1460SRT-1460SirtuinInhibitorinhibitorinhibit

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SRT 1460
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