1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SIRT-IN-3

SIRT-IN-3 

Cat. No.: HY-133998 Purity: 99.12%
Handling Instructions

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).

For research use only. We do not sell to patients.

SIRT-IN-3 Chemical Structure

SIRT-IN-3 Chemical Structure

CAS No. : 1211-19-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].

In Vitro

SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].

Molecular Weight

212.25

Formula

C₁₃H₁₂N₂O

CAS No.

1211-19-4

SMILES

O=C(N)C1=CC=CC=C1NC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1177.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7114 mL 23.5571 mL 47.1143 mL
5 mM 0.9423 mL 4.7114 mL 9.4229 mL
10 mM 0.4711 mL 2.3557 mL 4.7114 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SIRT-IN-3Sirtuinp53acetylationHCT116cells2-AnilinobenzamideInhibitorinhibitorinhibit

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Product Name:
SIRT-IN-3
Cat. No.:
HY-133998
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