Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

  • Bioorg Med Chem. 2009 Aug 15;17(16):5900-5. doi: 10.1016/j.bmc.2009.07.001.
Takayoshi Suzuki  1 ,  Keiko Imai ,  Erika Imai ,  Shinsuke Iida ,  Ryuzo Ueda ,  Hiroki Tsumoto ,  Hidehiko Nakagawa ,  Naoki Miyata
Affiliations
PMID: 19616958 DOI: 10.1016/j.bmc.2009.07.001
Abstract

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.