EGFR/HDAC-IN-2
EGFR/HDAC-IN-2 (Compound 38) is dual-functional inhibitor of EGFR and HDAC3 with IC50s of 20.34 and 1.09 nM for CDK9 and HDAC3, respectively. EGFR/HDAC-IN-2 has superior anti-proliferative activity against cancer cells, inhibits cell migration and induces late-stage cell apoptosis. EGFR/HDAC-IN-2 significantly inhibits triple-negative breast cancer (TNBC) tumor growth in xenograft mouse models. EGFR/HDAC-IN-2 can be used for cancers like TNBC research.
For research use only. We do not sell to patients.
- Formula: C21H15F3N2O2
- Molecular Weight:384.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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HDAC3 1.09 nM (IC50) |
EGFR 20.34 nM (IC50) |
Chemical Information
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Molecular Weight 384.35
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Formula C21H15F3N2O2
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SMILES
O=C(NCC1=CC=CC(F)=C1)C2=CC=C(NC(C3=CC=CC=C3F)=O)C=C2F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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