2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-52

HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer.

For research use only. We do not sell to patients.

HDAC-IN-52 Chemical Structure

HDAC-IN-52 Chemical Structure

CAS No. : 2075787-77-6

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Based on 1 publication(s) in Google Scholar

HDAC-IN-52 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer[1].

IC50 & Target[1]

hHDAC1

0.189 μM (IC50)

hHDAC2

0.227 μM (IC50)

hHDAC3

0.440 μM (IC50)

hHDAC10

0.446 μM (IC50)

In Vitro

HDAC-IN-52 (compound 8f) (72 hours) inhibits the proliferation of HCT116, A549 and K562 cells, with IC50s of 0.43, 1.28, and 0.37 μM, respectively[1].
HDAC-IN-52 (1-5 μM; 24-48 h) induces remarkable leukaemia U937 cell death after 48 h, with 76% and 100% pre-G1 phase arrest, respectively[1].
HDAC-IN-52 (1-5 μM; 48 h) increases mRNA expression of p21, BAX and BAK, downregulated cyclin D1 and BCL-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-52 Related Antibodies
Molecular Weight

396.44

Formula

C24H20N4O2
CAS No.
SMILES

NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(CC3=CC4=C(C=C3)C=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-52 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-522075787-77-6HDACHistone deacetylasesInhibitorinhibitorinhibit

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