ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin (CRT) exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cell), and inhibits tumor growth and activates T cells without apparent toxicity.
For research use only. We do not sell to patients.
- Formula: C19H22N4O3S
- Molecular Weight:386.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ROCK1 254.9 nM (IC50) |
ROCK2 58.18 nM (IC50) |
HDAC1 9.09 nM (IC50) |
HDAC2 8.03 nM (IC50) |
HDAC3 6.26 nM (IC50) |
HDAC6 0.41 nM (IC50) |
HDAC8 7.69 nM (IC50) |
Chemical Information
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Molecular Weight 386.47
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Formula C19H22N4O3S
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SMILES
O=C(NCCCCCCC(NO)=O)C1=CC2=CC(C3=CNN=C3)=CC=C2S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ROCK/HDAC-IN-1 Related Classifications
HY-168650 Related Classifications
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