1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. NKL 22

NKL 22 

Cat. No.: HY-100384 Purity: 97.97%
Handling Instructions

NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

For research use only. We do not sell to patients.

NKL 22 Chemical Structure

NKL 22 Chemical Structure

CAS No. : 537034-15-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 240 In-stock
Estimated Time of Arrival: December 31
100 mg USD 440 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice[1][2][3].

IC50 & Target[1]

HDAC1

0.199 μM (IC50)

HDAC2

1.59 μM (IC50)

HDAC3

0.069 μM (IC50)

HDAC8

5 μM (IC50)

Molecular Weight

325.40

Formula

C₁₉H₂₃N₃O₂

CAS No.

537034-15-4

SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (89.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NKL 22NKL22NKL-22HDACHistone deacetylaseshistonedeacetylasesphenotypetranscriptionalabnormalitiesHuntington'sInhibitorinhibitorinhibit

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Product Name:
NKL 22
Cat. No.:
HY-100384
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