1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. NKL 22

NKL 22 

Cat. No.: HY-100384 Purity: 97.97%
Handling Instructions

NKL 22 is a HDAC inhibitor.

For research use only. We do not sell to patients.

NKL 22 Chemical Structure

NKL 22 Chemical Structure

CAS No. : 537034-15-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
25 mg USD 204 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 660 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE NKL 22

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Description

NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrations NKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes. HDAC inhibitors act directly on FXN. [1]

IC50 & Target

HDAC

78 μM (IC50, in HeLa nuclear)

Molecular Weight

325.40

Formula

C₁₉H₂₃N₃O₂

CAS No.

537034-15-4

SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (89.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product name:
NKL 22
Cat. No.:
HY-100384
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