1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. NKL 22

NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

For research use only. We do not sell to patients.

NKL 22 Chemical Structure

NKL 22 Chemical Structure

CAS No. : 537034-15-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 40 In-stock
Solution
10 mM * 1 mL in DMSO USD 40 In-stock
Solid
5 mg USD 37 In-stock
10 mg USD 60 In-stock
50 mg USD 240 In-stock
100 mg USD 440 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NKL 22

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Description

NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice[1][2][3].

IC50 & Target[1]

HDAC1

0.199 μM (IC50)

HDAC2

1.59 μM (IC50)

HDAC3

0.069 μM (IC50)

HDAC8

5 μM (IC50)

Molecular Weight

325.40

Formula

C19H23N3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (307.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0731 mL 15.3657 mL 30.7314 mL 76.8285 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL 15.3657 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL 7.6829 mL
15 mM 0.2049 mL 1.0244 mL 2.0488 mL 5.1219 mL
20 mM 0.1537 mL 0.7683 mL 1.5366 mL 3.8414 mL
25 mM 0.1229 mL 0.6146 mL 1.2293 mL 3.0731 mL
30 mM 0.1024 mL 0.5122 mL 1.0244 mL 2.5610 mL
40 mM 0.0768 mL 0.3841 mL 0.7683 mL 1.9207 mL
50 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5366 mL
60 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2805 mL
80 mM 0.0384 mL 0.1921 mL 0.3841 mL 0.9604 mL
100 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7683 mL
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NKL 22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NKL 22
Cat. No.:
HY-100384
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