AKAP8L - A-kinase anchoring protein 8 like Gene

Also Known as HA95; HAP95; NAKAP; NAKAP95

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26993

About AKAP8L

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,380,050-15,418,988 (from NCBI)

This gene has 39 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 21.2), testis (RPKM 18.0) and 25 other tissues.

Summary

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including mitotic chromosome condensation; regulation of histone modification; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

AKAP8L Products (2)

mRNA	Protein	Name
NM_001291478.2	NP_001278407.1	A-kinase anchor protein 8-like isoform 2
NM_014371.4	NP_055186.3	A-kinase anchor protein 8-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	16980585	GOA
enables lamin binding	IDA IDA: Inferred from direct assay	11034899	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11402034	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell cycle G2/M phase transition	IMP IMP: Inferred from mutant phenotype	16980585	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	17594903	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	11034899	GOA
involved in nuclear membrane disassembly	IMP IMP: Inferred from mutant phenotype	11034899	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11884601	GOA
involved in regulation of mRNA export from nucleus	IDA IDA: Inferred from direct assay	11402034	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	11034899	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11402034	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11034899	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	17594903	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11402034	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	11402034	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP8L Protein Structure

AKAP95

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300
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646 a.a.

Protein Preferred Names	Protein Names
A-kinase anchor protein 8-like	A kinase (PRKA) anchor protein 8-like

AKAP8L Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKAP8L	Q9ULX6	PCDHB14	Homo sapiens	Q9Y5E9	Validated Y2H	32296183
Intra	AKAP8L	Q9ULX6	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183
Intra	AKAP8L	Q9ULX6	SAMD4A	Homo sapiens	Q9UPU9-3	Validated Y2H	32296183
Intra	AKAP8L	Q9ULX6	HDAC3	Homo sapiens	O15379	Anti Bait CoIP	16980585
Cross	AKAP8L	Q9ULX6	Prpf40a	Mus musculus	Q9R1C7	Far-WB	16391387
Cross	AKAP8L	Q9ULX6	Prpf40a	Mus musculus	Q9R1C7	Y2H	16391387
Intra	AKAP8L	Q9ULX6	PTEN	Homo sapiens	P60484	Anti Bait CoIP	36950384
Intra	AKAP8L	Q9ULX6	CARHSP1	Homo sapiens	Q9Y2V2	Validated Y2H	32296183
Cross	AKAP8L	Q9ULX6	P29991-PRO_0000308465	Dengue virus type 2	P29991-PRO_0000308465	Y2H	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Greenberg Dysplasia	Hem Dysplasia Greenberg Skeletal Dysplasia Hem Skeletal Dysplasia GRBGD Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia Moth-Eaten Skeletal Dysplasia Chondrodystrophy, Hydropic And Prenatally Lethal Type Hydrops-Ectopic Calcification-Motheaten Syndrome Skeletal Dysplasia, Greenberg Type Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia Hem Hem/Greenberg Dysplasia Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00524	AKAP8L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AKAP8L	MGD	MGI:1860606
Macaca mulatta	AKAP8L	VGNC	VGNC:108460
Bos taurus	AKAP8L	VGNC	VGNC:25790
Rattus norvegicus	AKAP8L	RGD	RGD:1359200
Felis catus	AKAP8L	VGNC	VGNC:69344
Canis familiaris	AKAP8L	VGNC	VGNC:37762
Others	AKAP8L	NCBI