2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-41

HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity.

For research use only. We do not sell to patients.

HDAC-IN-41

HDAC-IN-41 Chemical Structure

CAS No. : 2490309-83-4

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HDAC-IN-41 Related Antibodies

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Description

HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].

IC50 & Target

HDAC1

0.62 μM (IC50)

HDAC3

0.62 μM (IC50)

HDAC2

1.46 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.98 μM
Compound: 65
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
HCT-116 IC50
0.77 μM
Compound: 65
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
HEL IC50
0.41 μM
Compound: 65
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
HeLa IC50
1.5 μM
Compound: 65
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
Jurkat IC50
0.77 μM
Compound: 65
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
MOLT-4 IC50
0.54 μM
Compound: 65
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
PC-3 IC50
2.5 μM
Compound: 65
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37487305]
In Vitro

HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC50 values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-41 Related Antibodies
In Vivo

HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

446.48

Formula

C20H22N4O6S
CAS No.
SMILES

O=S(C1=[N+]([O-])ON=C1OCCCCCC(NC2=C(N)C=CC=C2)=O)(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-412490309-83-4HDACHistone deacetylasesHCT116NO releasingMS275Inhibitorinhibitorinhibit

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