2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC3-IN-T247

HDAC3-IN-T247 

Cat. No.: HY-123295
COA Handling Instructions

HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells.

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HDAC3-IN-T247 Chemical Structure

HDAC3-IN-T247 Chemical Structure

CAS No. : 1451042-18-4

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Description

HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].

IC50 & Target

HDAC3

0.24 μM (IC50)

HDAC1

19 μM (IC50)

HDAC4

>100 μM (IC50)

HDAC6

>100 μM (IC50)

HDAC8

>100 μM (IC50)

Molecular Weight

389.47

Appearance

Solid

Formula

C21H19N5OS
CAS No.
SMILES

O=C(C1=CC=C(C2=CN(CCC3=CSC=C3)N=N2)C=C1)NC4=C(N)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

HDAC3-IN-T2471451042-18-4HDACHistone deacetylasesHCT116 cellscolon cancerPC-3 cellsprostate canceranticancerantiviral agentHIV-infected cellsInhibitorinhibitorinhibit

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