1451042-18-4
1451042-18-4
Chemical Structure
HDAC3-IN-T247
- CAS No.: 1451042-18-4
- Formula:C21H19N5OS
- Molecular Weight:389.47
IUPAC Name: N-(2-aminophenyl)-4-(1-(2-(thiophen-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)benzamide
InChIKey: LBLSLSOENGWIHL-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CN(CCC3=CSC=C3)N=N2)C=C1)NC4=C(N)C=CC=C4
Biological Activity: HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].
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HDAC3-IN-T247 | 98.35% | HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells. | ||||||||||||||||||||
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