HDAC6-IN-14
HDAC6-IN-14 is a highly selective HDAC6 (HDAC) inhibitor with an IC50 of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4.
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- CAS No.: 3023019-97-5
- 화학식: C24H30FN3O4
- 분자량:443.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
HDAC6 42 nM (IC50) |
HDAC1 8.01 μM (IC50) |
HDAC2 4.48 μM (IC50) |
HDAC3 8.35 μM (IC50) |
HDAC4 >10 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HAL-01 | IC50 |
>25 μM
Compound: 10p
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Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 36351184] |
| HL-60 | IC50 |
12.2 μM
Compound: 10p
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
|
[PMID: 36351184] |
| Jurkat | IC50 |
>25 μM
Compound: 10p
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Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
|
[PMID: 36351184] |
In Vitro
HDAC6-IN-14 (compound 10p; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].
HDAC6-IN-14 (compound 10p; 6-36 μM; 24 h) treatment induces acetylation of α-tubulin but has no effect on Ac-H3 levels even at concentrations of ≤36 μM in HL60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HL60 cells
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Concentration:1 μM and 5 μM
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Incubation Time:48 h
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Result:Resulted in a significant apoptosis induction.
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Cell Line:HL60 cells
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Concentration:6 μM, 12 μM, 24 μM, 36 μM
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Incubation Time:24 h
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Result:Induced acetylation of α-tubulin but had no effect on Ac-H3 levels.
Chemical Information
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CAS No. 3023019-97-5
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분자량 443.51
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화학식 C24H30FN3O4
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SMILES
O=C(NO)C1=CC=C(CN(CC(NC(C)(C)C)=O)C(C2=CC=CC=C2C(C)C)=O)C(F)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-14 Related Classifications
HY-151896 Related Classifications
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