HDAC6-IN-14
HDAC6-IN-14 is a highly selective HDAC6 (HDAC) inhibitor with an IC50 of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4.
For research use only. We do not sell to patients.
- CAS No.: 3023019-97-5
- Formula: C24H30FN3O4
- Molecular Weight:443.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 42 nM (IC50) |
HDAC1 8.01 μM (IC50) |
HDAC2 4.48 μM (IC50) |
HDAC3 8.35 μM (IC50) |
HDAC4 >10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HAL-01 | IC50 |
>25 μM
Compound: 10p
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Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 36351184] |
| HL-60 | IC50 |
12.2 μM
Compound: 10p
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 36351184] |
| Jurkat | IC50 |
>25 μM
Compound: 10p
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Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 36351184] |
HDAC6-IN-14 (compound 10p; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].
HDAC6-IN-14 (compound 10p; 6-36 μM; 24 h) treatment induces acetylation of α-tubulin but has no effect on Ac-H3 levels even at concentrations of ≤36 μM in HL60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60 cells
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Concentration:1 μM and 5 μM
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Incubation Time:48 h
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Result:Resulted in a significant apoptosis induction.
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Cell Line:HL60 cells
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Concentration:6 μM, 12 μM, 24 μM, 36 μM
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Incubation Time:24 h
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Result:Induced acetylation of α-tubulin but had no effect on Ac-H3 levels.
Chemical Information
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CAS No. 3023019-97-5
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Molecular Weight 443.51
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Formula C24H30FN3O4
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SMILES
O=C(NO)C1=CC=C(CN(CC(NC(C)(C)C)=O)C(C2=CC=CC=C2C(C)C)=O)C(F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-14 Related Classifications
HY-151896 Related Classifications
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