2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC DNA Methyltransferase
  4. CM-444

CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models.

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CM-444

CM-444 Chemical Structure

CAS No. : 2256079-52-2

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CM-444 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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DNA Methyltransferase DNMT1 DNMT3 MGMT

  • Biological Activity

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Description

CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].

IC50 & Target

HDAC1

6.55 nM (IC50)

HDAC10

15 nM (IC50)

HDAC3

18 nM (IC50)

HDAC2

51 nM (IC50)

HDAC5

59 nM (IC50)

HDAC4

62 nM (IC50)

HDAC8

83 nM (IC50)

HDAC9

90 nM (IC50)

HDAC7

120 nM (IC50)

HDAC6

531 nM (IC50)

HDAC11

567.5 nM (IC50)

DNMT3A

1.8 μM (IC50)

DNMT1

2.2 μM (IC50)

DNMT3B

2.3 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
JJN-3 GI50
482 nM
Compound: 12a
Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
[PMID: 33661013]
MM1.S GI50
32 nM
Compound: 12a
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
[PMID: 33661013]
NCI-H929 GI50
103 nM
Compound: 12a
Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
[PMID: 33661013]
Molecular Weight

518.56

Formula

C27H30N6O5
CAS No.
SMILES

O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CM-444 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM-4442256079-52-2CM444CM 444HDACDNA MethyltransferaseHistone deacetylasesDNMTsDNA MTasesAMLacute myeloid leukemiaHL-60ML-2MV4-11MOLM-13anti-leukemicBALB/c mouseInhibitorinhibitorinhibit

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CM-444
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HY-163803
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